期刊
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
卷 23, 期 5, 页码 1033-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.hoc.2009.07.002
关键词
Acute lymphoblastic; Leukemia; Adolescents; Young adults; Treatment
资金
- RETICS [RD06/0020/1056]
- Fondo de Investigaciones Sanitarias [P1051490]
- Jose Carreras Leukemia Foundation [FIJC P/EF-08]
- Universitat Autonoma de Barcelona, Badalona, Spain [08916]
Today, long-term survival is achieved in more than 80% of children 1 to 10 years old with acute lymphoblastic leukemia (ALL). However, cure rates for adults and adolescents and young adults (AYA) with ALL remain relatively low, at only 40% to 50%. Age is a continuous prognostic variable in ALL, with no single age at which prognosis deteriorates markedly. Within childhood ALL populations, older children have shown inferior outcomes, whereas younger adults have shown superior outcomes among adult ALL patients. The type of treatment (pediatric-based versus adult-based) for AYA has recently been a matter of debate. In this article the biology and treatment of ALL in AYA is reviewed.
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