期刊
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
卷 23, 期 3, 页码 383-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.hoc.2009.03.010
关键词
Melanoma; Risk factors; Nevi; UV; Genetics
资金
- NCI, NIH
- NATIONAL CANCER INSTITUTE [ZIACP004410] Funding Source: NIH RePORTER
Melanoma is a complex, heterogeneous cancer that continues to increase in incidence. Multiple studies have consistently identified major host and environmental risk factors for melanoma. Nevi, particularly dysplastic nevi, confer much higher risks than most pigmentary characteristics. Ultraviolet radiation exposure is the predominant environmental risk factor for melanoma. Recently, both rare high risk susceptibility genes and common polymorphic genes contributing to melanoma risk have been identified.
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