Sesterterpenes and 2H-Pyran-2-ones (=α-Pyrones) from the Mangrove-Derived Endophytic Fungus Fusarium proliferatum MA-84

Two new tricyclic sesterterpenes, fusaprolifins A and B (1 and 2), and three new 2H-pyran-2-one derivatives, prolipyrones A C (35), were isolated and characterized from Fusarium proliferatum MA-84, an endophytic fungus obtained from the fresh tissue of the marine mangrove plant Bruguiera sexangula. In addition, two known sesterterpenes, terpestacin (6) and fusaproliferin (7), and one known 2H-pyran-2-one derivative, gibepyrone D (8), were also identified. The structures of these compounds were elucidated by detailed spectroscopic analyses. Fusaprolifin A (1) showed moderate activity against brine shrimp (Artemia salina), with a lethality rate of 49.5% at 100g/ml, while fusaprolifin B (2) showed weak activity.