期刊
HELVETICA CHIMICA ACTA
卷 95, 期 6, 页码 973-982出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/hlca.201100437
关键词
Xyloallenoides A and A1; Cyclopeptides; Cytotoxic activity
资金
- 863-Foundation of China [2006A092422, 2006A092419]
- National Natural Science Foundation of China [20572136]
- Guangdong Provincial Public Laboratory of Food Industry, China
The novel natural product xyloallenoide A, isolated from the marine mangrove endophytic fungus from the South China Sea, and its diastereoisomer xyloallenoide A1, which contain N-methyl-substituted amino acids, were synthesized. The absolute configurations of the amino acid units of xyloallenoide A were finally confirmed to be L-Lys, Me-D-Val, and Me-L-Ala. This report represents a practical and attractive alternative for the synthesis of N-methyl-substituted cyclotripeptides. In the preliminary bioassay, synthetic xyloallenoide A showed marginal activities against KB (IC50=9.6 mu M) and KBv200 cells (IC50=10.3 mu M), and xyloallenoide A1 was inactive against KB and KBv200 cells.
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