Anthracene and Anthraquinone Derivatives from the Stem Bark of Juglans mandshurica MAXIM.

One new anthracene derivative, juglanthracenoside A (1), two new anthraquinones, juglanthraquinone A (2) and juglanthraquinone B (3), along with a new naturally occurring anthraquinone, 9,10-dihydro- 4,8-dihydroxy-9,10-dioxoanthracene-2-carboxylic acid (4), have been isolated from the stem bark of Juglans mandshurica. Their structures were established by detailed spectroscopic analysis and comparison of the NMR data with those of related compounds. Compound 1 displayed noticeable antioxidant activity in both 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2'-azinobis(3-ethylbenzothiazoline- 6-sulfonic acid) (ABTS) free radical-scavenging assays, while compound 4 showed strong cytotoxicity against HepG2, SGC7901, HCT-8, and A549 cell lines in vitro.