期刊
HELICOBACTER
卷 20, 期 1, 页码 11-18出版社
WILEY
DOI: 10.1111/hel.12170
关键词
Hepcidin; HP-related iron-deficiency anemia; hyperplastic polyp; hypochlorhydria; nodular gastritis
Background and aimsHelicobacter pylori (H. pylori) is recognized as a causative agent for unexplained iron-deficiency anemia (IDA). We evaluated many background factors influencing an iron-deficiency state in adult patients with various H.pylori-infected upper gastrointestinal tract diseases. MethodStudy 1: H.pylori-infected 121 patients (nodular gastritis (NG) (n=19), duodenal ulcer (DU) (n=30), or gastric ulcer (GU) (n=47), or gastric hyperplastic polyp (GHP) (n=25)) were enrolled. The RBC count and hemoglobin, iron, ferritin, pepsinogen (PG) I, PG II, gastrin, and anti-H. pylori antibody (Ab) levels in the serum were measured. Study 2: H.pylori-infected 105 patients (NG, n=19; DU, n=43; GU, n=32; GHP, n=11) and non-H.pylori-infected individuals (n=35) were examined for the levels of prohepcidin, ferritin, and iron in the serum. In addition, we measured the data before and after the H.pylori eradication. ResultsIn the patients with GHP and NG, hypoferritinemia was observed in comparison with the GU and DU patients. In the GHP patients, low levels of PG I, a decreased PG I/II ratio, and hypergastrinemia were observed. The levels of serum prohepcidin in the patients with H.pylori-associated disease were higher than those in the uninfected adults. In the patients with NG, the serum prohepcidin levels were higher than those in the other H.pylori-infected patient groups and decreased after the eradication. ConclusionH.pylori-related iron-deficiency state might be associated with several factors, such as hypochlorhydria and hepcidin, in patients with GHP or NG.
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