期刊
HELICOBACTER
卷 19, 期 1, 页码 55-64出版社
WILEY
DOI: 10.1111/hel.12098
关键词
Active infection by H; pylori; CagA H; pylori strains; evidence of past infection by H; pylori; Helicobacter pylori; serological tests to H; pylori; urea breath test
资金
- National Council of Science and Technology [69667]
- Fund of Health Research, Mexican Institute of Social Security [2005/1/I/089, 190]
BackgroundIn developing countries, more than 50% of children have serological evidence of Helicobacter pylori infection. However, serological tests for H.pylori did not differentiate between active and past infection. The objectives of this study were to estimate the frequency of active and past H.pylori infection utilizing functional urea breath test (UBT) and serological tests and evaluate factors associated with the infection. MethodsA total of 675 school children, 6-13years of age, participated. UBT was performed to detect active H.pylori infection. Blood samples were obtained to determine iron status and Immunoglobulin G (IgG) responses to the H.pylori whole-cell and to Cag A antigens by antigen-specific enzyme-linked immunosorbent assays. Weight, height, and sociodemographic characteristics were recorded. ResultsA total of 37.9% (95% Confidence Intervals (CI): 34.2-41.6) of school children had active or past H.pylori infection; of them, 73.8% (CI95% 68.4-79.2) were carrying CagA-positive strain, 26.5% (CI95% 23.2-29.8) had active infection, and 11.4% (95%CI: 9.0-13.8) had evidence of past H.pylori infection. School children with iron deficiency and low height for age had higher risk of H.pylori infection: [OR to active or past infection was 2.30 (CI 95% 1.01-5.23) and to active infection it was 2.64 (CI 95% 1.09-6.44)] compared to school children with normal iron status and height for age or with normal iron status but low height for age or with iron deficiency and normal height for age. ConclusionsThe estimated prevalence of infection depends of the test utilized. Frequency of H.pylori infection and carrying CagA-positive strains was high in this population. Malnutrition was associated with active H.pylori infection.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据