期刊
HELICOBACTER
卷 16, 期 2, 页码 146-152出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1523-5378.2011.00829.x
关键词
Helicobacter pylori; sequential therapy; clinical trial; amoxicillin; clarithromycin; proton-pump inhibitor; metronidazole
资金
- National Science Council of the ROC [NSC-98-2314B- 037-004-MY2, NSC99-2314-B-075B-009]
- Cancer Research Center, Department of Health, Executive Yuan, Taiwan [DOH100-TD-C-111-002]
- Center of Excellence for Environmental Medicine
- Kaohsiung Medical University
- National Sun Yat-Sen University-Kaohsiung Medical University Joint Center
- Public Health Service [DK56338]
- Texas Medical Center Digestive Diseases Center [R01 CA116845]
Background and Aims: Ten-day sequential therapy with a proton-pump inhibitor (PPI) and amoxicillin followed by a PPI, clarithromycin, and an imidazole typically achieves Helicobacter pylori (H. pylori) eradication rates between 90 and 94% (i.e., Grade B success). It has been suggested that prolonging the duration of therapy might improve the treatment success. We tested whether prolonging treatment duration to 14-days would improve the results to 95% or greater eradication. Methods: This was a multi-center, single site, pilot study in which H. pylori-infected patients received a 14-day sequential therapy (esomeprazole and amoxicillin for 7 days followed by esomeprazole, clarithromycin, and metronidazole for 7 days). H. pylori status was assessed 8 weeks after therapy. Success was defined as achieving 95% or greater eradication by per-protocol (PP) analysis. Results: One hundred and twenty-three subjects received the 14-day sequential therapy. The eradication rate was 93.9% (95% confidence interval [CI], 89.5-98.3%) by PP and 91.9% (95% CI, 87.1-96.7%) by intention-to-treat analysis. Adverse events were experienced by 21.1%; compliance of 90% or greater was 95.9%. Conclusions: Extending sequential therapy to 14 days did not result in improving the treatment outcome to 95% or greater.
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