Acute electrical and hemodynamic effects of multisite left ventricular pacing for cardiac resynchronization therapy in the dyssynchronous canine heart

BACKGROUND Multisite left ventricular (multi-LV) epicardial pacing has been proposed as an alternative to conventional single-site LV (single-LV) pacing to increase the efficacy of cardiac resynchronization therapy. OBJECTIVE To compare the effects of multi-LV versus single-LV pacing in dogs with left bundle branch block (LBBB). METHODS Studies were performed in 9 anaesthetized dogs with chronic LBBB using 7 LV epicardial electrodes. Each electrode was tested alone and in combination with 1, 2, 3, and 6 other electrodes, the sequence of which was chosen on the basis of practical real-time electrical mapping to determine the site of the latest activation. LV total activation time (LVTAT) and dispersion of repolarization (DRep) were measured by using approximately 100 electrodes around the ventricles. LV contractility was assessed as the maximum derivative of left ventricular pressure (LVdP/dt(max)). RESULTS Single-LV pacing provided, on average, a -4.0% +/- 9.3% change in LVTAT and 0.2% +/- 13.7% change in DRep. Multi-LV pacing markedly decreased both LVTAT and DRep in a stepwise fashion to reach -41.3% +/- 5% (P < .001 for overall comparison) and -14.2% +/- 19.5% (P < .02 for overall comparison) in the septuple-LV pacing configuration, respectively. Single-LV pacing provided a mean increase of 10.7% +/- 7.7% in LVdP/dt(max). LVdP/dt(max) incrementally increased by the addition of pacing electrodes to 16.4% +/- 8.7% (P < .001 for overall comparison). High response to single-LV pacing could not be improved further during multi-LV pacing. CONCLUSIONS Compared with single-LV pacing, multi-LV pacing can considerably reduce both LVTAT and DRep in dogs with LBBB, but the improvement in contractility is limited to conditions where single-LV pacing provides suboptimal improvement. Further studies are warranted to determine whether these acute effects translate in antiarrhythmic properties and better Long-term outcomes.