期刊
HEART RHYTHM
卷 11, 期 11, 页码 1853-1859出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.hrthm.2014.07.032
关键词
Atrial fibrillation; Stroke; LARIAT; Left atrial appendage
资金
- SentreHeart
- Boston Scientific
- St. Jude Medical
- Coherex Medical
BACKGROUND Pericardial suture ligation of the left atrial appendage (LAA) may be an alternative to endoluminal devices for stroke prevention in patients with atrialfibrillation, but multicenter safety and efficacy data in high-risk patients with contraindications to oral anticoagulation are lacking. OBJECTIVE The purpose of this study was to report the outcomes of consecutive cases of pericardial suture ligation of the LAA in high-risk patients performed at 4 centers. METHODS The cohort included 41 consecutive patients who underwent LAA closure with the LARIAT system. Epicardial and transeptal access was obtained, and the epicardial snare was advanced over an endo-epicardial magnetic-tipped guidewire to close the LAA. Transesophageal echocardiography was used to confirm LAA exclusion. RESULTS Mean age was 75 +/- 10 years, mean CHADS2 score was 3.0 +/- 1.3, and mean HAS-BLED score was 4.4 +/- 1.4. These patients accumulated 24 +/- 6 person-years of follow-up. Acute LAA closure was achieved in 38 patients (93%). Transesophageal echocardiography or computerized tomographic angiography performed up to 3.3 +/- 0.8 months after the procedure demonstrated LAA leakage in 240/a of patients. One patient (2%) had a transient ischemic attack, and 8 (20%) developed pericardial effusions requiring pericardiocentesis. Four cases (9%) were complicated by perforation of the LAA, with 2 of these patients requiring open surgical correction. CONCLUSION This multicenter experience revealed that pericardial suture ligation with the LARIAT system is technically feasible and acutely efficacious. However, additional improvements are required to minimize the rate of pericardial complications. A randomized study is warranted to accurately define the long-term efficacy and safety profile of percutaneous epicardial suture ligation.
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