期刊
HEART RHYTHM
卷 10, 期 3, 页码 315-319出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.hrthm.2012.12.001
关键词
Atrial fibrillation; Smartphone; Detection; Technology
资金
- Office of Naval Research work unit [N00014-12-1-0171]
- National Institutes of Health [1U01HL105268-01, KL2RR031981]
BACKGROUND Atrial fibrillation (AF) is common and associated with adverse health outcomes. Timely detection of AF can be challenging using traditional diagnostic took. Smartphone use is increasing and may provide an inexpensive and user-friendly means to diagnose AF. OBJECTIVE To test the hypothesis that a smartphone-based application could detect an irregular pulse from AF. METHODS Seventy-six adults with persistent AF were consented for participation in our study. We obtained pulse time series recordings before and after cardioversion using an iPhone 4S camera. A novel smartphone application conducted rea-time pulse analysis using 2 statistical methods: root mean square of successive RR difference (RMSSD/mean) and Shannon entropy (ShE). We examined the sensitivity, specificity, and predictive accuracy of both algorithms using the 12-lead electrocardiogram as the god standard. RESULTS RMSDD/mean and ShE were higher in participants in AF than in those with sinus rhythm. The 2 methods were inversely related to AF in regression models adjusting for key factors including heart rate and blood pressure (beta coefficients per SD increment in RMSDD/mean and ShE were -0.20 and -0.35; P < .001). An algorithm combining the 2 statistical methods demonstrated excellent sensitivity (0.962), specificity (0.975), and accuracy (0.968) for beat-to-beat discrimination of an irregular pulse during AF from sinus rhythm. CONCLUSIONS In a prospectively recruited cohort of 76 participants undergoing cardioversion for AF, we found that a novel algorithm analyzing signals recorded using an iPhone 4S accurately distinguished pulse recordings during AF from sinus rhythm. Data are needed to explore the performance and acceptability of smartphone-based applications for AF detection.
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