期刊
HEART RHYTHM
卷 9, 期 4, 页码 570-578出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.hrthm.2011.11.004
关键词
chronic heart failure; early afterdepolarizations; Na+/Ca2+ exchanger; SEA0400; ventricular tachyarrhythmias
资金
- Peter Osypka Foundation
- Deutsche Forschungsgemeinschaft [DFG-Po-1004-1/2]
- Innovative Medical Program Munster [IMF Po-120607]
- British Hear Foundation [PG/08/019]
- IZKF Munster (Core Unit ECHO)
- Deutsche Forschungsgemeinschaft [Collaborative-Research-Group-656(MoBil)]
BACKGROUND Molecular remodeling in heart failure includes slowing of repolarization, leading to proarrhythmia. OBJECTIVE To evaluate the effects of Na+/Ca2+ exchanger (NCX) inhibition on repolarization as a novel antiarrhythmic concept in chronic heart failure (CHF). METHODS AND RESULTS CHF was induced by rapid ventricular pacing in rabbits. Left ventricular function was assessed by echocardiography. Monophasic action potentials (MAPs) showed a prolongation of repolarization in CHF after atrioventricular block and stimulation at different cycle lengths. Sotalol (100 mu M, n = 13) or veratridine (0.5 mu M; n = 15) resulted in a further significant increase in the MAP duration. CHF was associated with an increased dispersion of repolarization, as compared with sotaloltreated (+22 +/- 7 ms; P < .05) and veratridine-treated (+20 +/- 6 ms; P < .05) sham hearts. In the presence of a low potassium concentration, sotalol and veratridine reproducibly induced early afterdepolarizations (EADs) and polymorphic ventricular tachyarrhythmias (VTs). SEA0400 (1 mu M), a pharmacological inhibitor of NCX, significantly shortened the MAP duration (P < .01) and reduced dispersion (P < .05). It suppressed EAD in 6 of 13 sotalol-treated failing hearts and in 9 of 10 veratridine-treated failing hearts, leading to a reduction in VT (60% in sotalol-treated failing hearts and 83% in veratridine-treated failing hearts). Simulations using a mathematical model showed a reduction in the action potential duration and the number of EADs by the NCX block in all subgroups. CONCLUSIONS In an experimental model of CHF, the acute inhibition of NCX (1) reduces the MAP duration, (2) decreases dispersion of repolarization, and (3) suppresses EAD and VT. Our observations indicate for the first time that pharmacological NCX inhibition increases repolarization reserve and protects against VTs in heart failure.
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