期刊
HEART RHYTHM
卷 5, 期 5, 页码 749-757出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.hrthm.2008.02.010
关键词
cardiac stem cells; biopsy; myocardial infarction; myocardial regeneration
资金
- NHLBI NIH HHS [R01 HL083109-04, R01 HL083109] Funding Source: Medline
New approaches for cardiac repair have been enabled by the discovery that the heart contains its own reservoir of stem cells. These cells are positive for various stem/progenitor cell markers, are self-renewing, and exhibit multilineage differentiation potential. Recently we developed a method for ex vivo expansion of cardiac-derived stem cells from human myocardial biopsies with a view to subsequent autologous transplantation for myocardial regeneration. Here we review the state of the cardiac stem cell field and our own work on cardiosphere-derived stem cells from human hearts. The first of this two-part review outlines emerging preclinical data on the application of cardiac stem cells. Part 2 continues with a discussion of other stem cell sources with clinical potential, a summary of the critical issues surrounding stem cell therapy (with an emphasis on the crucial issue of how cell transplantation may influence arrhythmias), our perception of clinical stem cell trials to date, and the issues facing the clinical application of cardiac stem cells.
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