期刊
HEART FAILURE REVIEWS
卷 15, 期 5, 页码 467-477出版社
SPRINGER
DOI: 10.1007/s10741-010-9163-9
关键词
Resveratrol; Red wine; White wine; Cardioprotection; Longevity genes; Anti-aging; SIRT; FoxO; PBEF
资金
- NH [HL 34360, HL22559, HL33889]
Resveratrol, a polyphenol phytoalexin, present in red wine and grapes possesses diverse biochemical and physiological properties, including estrogenic, antiplatelet, and anti-inflammatory properties as well as a wide range of health benefits ranging from chemoprevention to cardioprotection. Recently, several studies described resveratrol as an anti-aging compound. This review focuses on the anti-aging aspects of resveratrol, the possible mechanisms of action, and emerging controversy on its life-prolonging ability. It appears that resveratrol can induce the expression of several longevity genes including Sirt1, Sirt3, Sirt4, FoxO1, Foxo3a and PBEF and prevent aging-related decline in cardiovascular function including cholesterol level and inflammatory response, but it is unable to affect actual survival or life span of mice.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据