期刊
HEART FAILURE REVIEWS
卷 15, 期 3, 页码 197-207出版社
SPRINGER
DOI: 10.1007/s10741-008-9114-x
关键词
Pharmacogenetics; Peroxisome proliferator-activated receptor; PPAR; PGC-1; ERR; Cardiovascular disease
资金
- NIH [P50 HL077113, 5 P60 DK20579, 1R21HL089681]
The PPAR gene pathway consists of interrelated genes that encode transcription factors, enzymes, and downstream targets which coordinately act to regulate cellular processes central to glucose and lipid metabolism. The pathway includes the PPAR genes themselves, other class II nuclear hormone receptor transcription factors within the PPAR family, PPAR co-activators, PPAR co-repressors, and downstream metabolic gene targets. This review focuses on the transcription factors that comprise the PPAR transcriptional activator complex-the PPARs (PPAR alpha, PPAR beta, or PPAR gamma), PPAR heterodimeric partners, such as RXR alpha, and PPAR co-activators, such as PPAR gamma coactivator 1 alpha (PGC-1 alpha) and the estrogen-related receptors (ERR alpha, ERR beta, and ERR gamma). These transcription factors have been implicated in the development of myocardial hypertrophy and dilated cardiomyopathy as well as response to myocardial ischemia/infarction and, by association, ischemic cardiomyopathy. Human expression studies and animal data are presented as the background for a discussion of the emerging field of pharmacogenetics as it applies to these genes and the consequent implications for the individualization of therapy for patients with heart failure.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据