期刊
HEART
卷 98, 期 7, 页码 536-543出版社
BMJ PUBLISHING GROUP
DOI: 10.1136/heartjnl-2011-300953
关键词
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资金
- MRC [G0701352, G0100188] Funding Source: UKRI
- Medical Research Council [G0100188, G0701352] Funding Source: researchfish
Mutations involving cardiac ion channels result in abnormal action potential formation or propagation, leading to cardiac arrhythmias. Despite the large impact on society of sudden cardiac death resulting from such arrhythmias, understanding of the underlying cellular mechanism is poor and clinical risk stratification and treatment consequently limited. Basic research using molecular techniques, as well as animal models, has proved extremely useful in improving our knowledge of inherited arrhythmogenic syndromes. This offers the practitioner tools to accurately diagnose rare disorders and provides novel markers for risk assessment and a basis for new strategies of treatment.
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