期刊
HEART
卷 98, 期 8, 页码 650-655出版社
BMJ PUBLISHING GROUP
DOI: 10.1136/heartjnl-2011-301185
关键词
-
资金
- Institut National de la Sante et de la Recherche Medicale (INSERM)
- Victor SegaleneBordeaux II University
- Sanofi-Aventis
- Fondation pour la Recherche Medicale
- Caisse Nationale Maladie des Travailleurs Salaries
- Direction Generale de la Sante
- MGEN
- Institut de la Longevite
- Conseils Regionaux of Aquitaine and Bourgogne
- Fondation de France
- Ministry of Researche-INSERM Programme Cohortes et collections de donnees biologiques.
Objectives To investigate the respective associations and clinical usefulness of the metabolic syndrome (MetS) and its individual components to predict the risk of first coronary heart disease (CHD) events in elderly. Design The Three-City is a French prospective multisite community-based cohort. Setting Three large French cities: Bordeaux, Dijon and Montpellier. Participants 7612 subjects aged 65 and over who were free of CHD at baseline. Main outcome measures The MetS was defined by the 2005 National Cholesterol Education Program Adult Treatment Panel III criteria. Results During a median follow-up of 5.2 years, 275 first CHD events were adjudicated. The MetS was associated with increased risks of total (adjusted HR: 1.78; 95% CI 1.39 to 2.28), fatal (HR: 2.40; 95% CI 1.41 to 4.09) and non-fatal (HR: 1.64; 95% CI 1.24 to 2.17) CHD events. The association with total CHD was significant in women (HR: 2.56; 95% CI 1.75 to 3.75) but not in men (HR: 1.39; 95% CI 0.99 to 1.94; p for interaction=0.012). When in the same multivariable model, hyperglycemia and abdominal adiposity in women, hyperglycemia, lower HDL cholesterol and abdominal adiposity (inverse association) in men were the components significantly associated with CHD. The components of the MetS but not the MetS itself improved risk prediction beyond traditional risk factors (NRI= 9.35%, p < 0;001). Conclusion The MetS is a risk marker for CHD in community-dwelling elderly subjects but may not be useful for CHD risk prediction purposes compared to its individual components.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据