期刊
LAB ON A CHIP
卷 15, 期 11, 页码 2460-2466出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5lc00351b
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- International Fragrances and Flavors
Coupling analog frequency modulation (FM) to the driving stimulus in active microrheology measurements conducted with optical tweezers effectively parallelizes numerous single-frequency experiments. Consequently, frequency modulated microrheology (FMMR) can efficiently characterize the dynamic stress response of complex fluids over several frequency decades in a single experiment. The time required to complete an FMMR measurement scales with the lowest frequency probed, improving throughput over the serial frequency sweep approach. The ease of implementation, straight-forward data analysis and rapidity of FMMR offer particular utility toward applications such as characterization of non-equilibrium materials, automated microrheology instrumentation, high-throughput screening of biomaterials and (bio) pharmaceutical formulations, and in situ monitoring of chemical and biochemical reaction processes.
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