期刊
LAB ON A CHIP
卷 15, 期 18, 页码 3785-3792出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5lc00729a
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资金
- Grand Challenges Canada
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- Ontario Centres of Excellence
We report a novel method for achieving consistent liquid phase solvent bonding of plastic microfluidic devices via the use of retention grooves at the bonding interface. The grooves are patterned during the regular microfabrication process, and can be placed at the periphery of a device, or surrounding microfluidic features with open ports, where they effectively mitigate solvent evaporation, and thus substantially reduce poor bond coverage. This method is broadly applicable to a variety of plastics and solvents, and produces devices with high bond quality (i.e., coverage, strength, and microfeature fidelity) that are suitable for studies in physics, chemistry, and cell biology at the microscale.
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