期刊
HEART
卷 95, 期 14, 页码 1165-1171出版社
B M J PUBLISHING GROUP
DOI: 10.1136/hrt.2008.160465
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资金
- Ministry of Health, Czech Republic [NR/9472- 3]
- University Hospital Motol, Prague, Czech Republic [64203]
Background: Cardiac resynchronisation therapy (CRT) is increasingly used in children in a variety of anatomical and pathophysiological conditions, but published data are scarce. Objective: To record current practice and results of CRT in paediatric and congenital heart disease. Design: Retrospective multicentre European survey. Setting: Paediatric cardiology and cardiac surgery centres. Patients: One hundred and nine patients aged 0.24-73.8 (median 16.9) years with structural congenital heart disease (n=87), congenital atrioventricular block (n=12) and dilated cardiomyopathy (n=10) with systemic left (n=69), right (n=36) or single (n=4) ventricular dysfunction and ventricular dyssynchrony during sinus rhythm (n=25) or associated with pacing (n=84). Interventions: CRT for a median period of 7.5 months (concurrent cardiac surgery in 16/109). Main outcome measures: Functional improvement and echocardiographic change in systemic ventricular function. Results: The z score of the systemic ventricular end-diastolic dimension decreased by median 1.1 (p < 0.001). Ejection fraction (EF) or fractional area of change increased by a mean (SD) of 11.5 (14.3)% (p < 0.001) and New York Heart Association (NYHA) class improved by median 1.0 grade (p < 0.001). Non-response to CRT (18.5%) was multivariably predicted by the presence of primary dilated cardiomyopathy (p=0.002) and poor NYHA class (p=0.003). Presence of a systemic left ventricle was the strongest multivariable predictor of improvement in EF/fractional area of change (p < 0.001). Results were independent of the number of patients treated in each contributing centre. Conclusion: Heart failure associated with ventricular pacing is the largest indication for CRT in paediatric and congenital heart disease. CRT efficacy varies widely with the underlying anatomical and pathophysiological substrate.
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