期刊
HEARING RESEARCH
卷 264, 期 1-2, 页码 10-20出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.heares.2010.02.001
关键词
Presbycusis; Age-related hearing loss; Audiometric configuration; ISO 7029; ANSI S3.44
资金
- USPHS [AG009524, DC005409]
Many reports have documented age-by-frequency increases in average auditory thresholds in various human populations. Despite this, the prevalence of different patterns of hearing loss in presbycusis remains uncertain. We examined 'presbycusis phenotypes' in a database of 960 subjects (552 female, 408 male, 18-92 years) that each had 30 measures of peripheral hearing sensitivity: pure tone audio-grams for left and right ears from 0.25 to 8 kHz and DPOAE for each ear with F(mean) = 1-6.4 kHz. Surprisingly, the hearing phenotypes did not naturally separate into discrete classes of presbycusis. Principal component (PC) analysis revealed that two principal components account for 74% of the variance among the 30 measures of hearing. The two components represent the overall degree (PC1) and configuration of loss (Flat vs. Sloping; PC2) and the phenotypes form a continuum when plotted against them. A heuristic partitioning of this continuum produced classes of presbycusis that vary in their degree of Sloping or Flat hearing loss, suggesting that the previously reported sub-types of presbycusis arise from the categorical segregation of a continuous and heterogeneous distribution. Further, most phenotypes lie intermediate to the extremes of either Flat or Sloping loss, indicating that if audiometric configuration does predict presbycusis etiology, then a mixed origin is the most prevalent. (C) 2010 Elsevier B.V. All rights reserved.
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