期刊
HEARING RESEARCH
卷 245, 期 1-2, 页码 82-91出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.heares.2008.09.002
关键词
Noise exposure; Long evans rats; Middle latency responses; Auditory brainstem responses; Amplitude-intensity functions
资金
- Grant Agency of the Czech Republic [AVOZ50390512, 309/07/1336]
- Internal Grant Agency of the Czech Ministry of Health [NR 8113-4]
- Center of Neuroscience [LC 554]
Auditory brainstem responses (ABRs) and middle latency responses (MLRs) were compared after noise exposure to elucidate the specific effects of a loud sound on the central auditory system in rats. Rats were exposed twice for I h to broad-band noise (BBN) of 118 dB SPL (first exposure) and 122 dB SPL (second exposure) with an interval between the exposures of three weeks. The first noise exposure produced threshold shifts (TSs) amounting to 5-45 dB, and the second exposure resulted in 40-70 dB TSs. The slope of MLR amplitude-intensity functions (AIFs) increased significantly in correlation with the TS, resembling loudness recruitment. However, maximal MLR amplitudes measured at 8 kHz increased after the first and second noise exposures to almost equal values in individual animals regardless of the TS. In addition, maximum MLR amplitude enhancement was dependent on pre-exposure MLR voltage, probably reflecting the level of metabolic activity or neurotransmitter processes in individual animals. In contrast to MLR amplitudes, ABR amplitudes were suppressed after noise exposure without changing the slope of ABR AIFs. The MLR changes reflect the specific effects of noise exposure on the central auditory system. (C) 2008 Elsevier B.V. All rights reserved.
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