Persistent Frequent Nausea Is Associated With Progression to Chronic Migraine: AMPP Study Results

BackgroundThough nausea is a cardinal feature of migraine, its influence on migraine progression has not been evaluated. This article aims to evaluate persistent frequent headache-related nausea (PFN) in persons with episodic migraine (EM) as a predictor of new onset chronic migraine (CM). MethodsThis prospective cohort study uses data from the 2007 and 2008 American Migraine Prevalence and Prevention study surveys to identify subgroups with episodic International Classification of Headache Disorders, 2nd edition defined migraine and either PFN or no or low frequency nausea (NLFN). PFN was defined by the presence of nauseahalf the time in both 2007 and 2008. NLFN was defined by nausea that was present