期刊
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
卷 37, 期 10, 页码 1448-1455出版社
WILEY-BLACKWELL
DOI: 10.1002/hed.23779
关键词
circulating tumor cells; podoplanin; head and neck squamous cell carcinoma; prognosis; and biomarker
资金
- National Science Council [NSC 99-2632-B-182-001-MY3, 99-2628-B-182-001-MY3, 102-2628-B-182-009-MY3, 102-2628-B-182-010-MY3]
- Chang Gung Memorial Hospital [CMRPD180423, CMRPD1B0392, CMRPD1C0551, CMRPG3B0973]
- Chang Gung Molecular Medicine Research Center [EMRPD1C0121]
Background. Podoplanin (PDPN) is a prognostic factor for head and neck squamous cell carcinoma (HNSCC). However, PDPN expression in circulating tumor cells (CTCs) and its prognostic value are not clear. Methods. The PowerMag system was used to enumerate CTCs from 53 patients with HNSCC prechemotherapy and 61 healthy donors. PDPN expression was determined by immunofluorescence staining. Results were correlated with clinicopathological parameters and clinical outcome, such as patient survival by receiver operating characteristic (ROC) and univariate and multivariate analyses. Results. PDPN was expressed in a subset of CTCs. Both EpCAM-positive CTC and PDPN-positive CTC counts were statistically different between the disease and nondisease groups (p<.0001) with no prognostic value. After a median follow-up of 10.5 months (range, 6.6-18.5 months), the PDPN-positive/EpCAM-positive CTC ratio >20% was a significant prognostic factor for death within 6 months (p=.011) and was correlated with poor progression-free survival (p=.016) and overall survival (p=.015). Conclusion. PDPN-positive/EpCAM-positive CTC ratio is a prognostic factor and defining the ratio in patients with HNSCC might be valuable to clinical management. (C) 2014 Wiley Periodicals, Inc.
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