期刊
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
卷 37, 期 9, 页码 1344-1348出版社
WILEY
DOI: 10.1002/hed.23746
关键词
laryngeal squamous cell carcinoma; B-crystallin; metastasis; quantitative real-time polymerase chain reaction (qRT-PCR); lymph node
资金
- Scientific Research Projects of Istanbul University [37541]
- Scientific and Technological Research Council of Turkey (TUBITAK) [210T009]
BackgroundLaryngeal squamous cell carcinoma (SCC), being an aggressive malignancy, is one of the most commonly diagnosed malignant types of head and neck SCC worldwide. The recent studies suggested that B-crystallin might play an important role in tumorigenesis. The purpose of this study was to investigate the B-crystallin expression level in metastatic and nonmetastatic laryngeal SCC tissues and to determine its prognostic significance. MethodsAlpha-B-crystallin expression status in metastatic, nonmetastatic laryngeal SCC, and normal tissue samples was investigated by quantitative real-time polymerase chain reaction (qRT-PCR). ResultsWe demonstrated that the expression of B-crystallin was significantly upregulated in laryngeal SCC tumor tissue samples in comparison with the corresponding normal tissues (p<.001), although no significant association has been found between B-crystallin expression and either the metastatic potential or the T classification of the specimens. ConclusionAlthough expression of B-crystallin is not statistically correlated with neck metastases, we demonstrated that B-crystallin is significantly overexpressed in laryngeal cancer. (c) 2014 Wiley Periodicals, Inc. Head Neck 37: 1344-1348, 2015
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