期刊
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
卷 36, 期 11, 页码 1611-1618出版社
WILEY-BLACKWELL
DOI: 10.1002/hed.23509
关键词
skin cancer; head and neck neoplasms; peripheral nerve neoplastic infiltration; perineurium; squamous cell carcinoma
资金
- Princess Alexandra Hospital Research Foundation
BackgroundNonmelanoma skin cancer (NMSC) with perineural invasion (PNI) is most commonly seen in cutaneous squamous cell carcinoma of the head and neck (SCCHN). The cranial nerves are a conduit for skin cancer to reach the brainstem. MethodsThe histopathological features of 51 tissue specimens from 49 patients with cutaneous SCCHN and clinical PNI were assessed with consecutive transverse and longitudinal sections. ResultsNo skip lesions were identified. Tumor spread was contiguous in all specimens. No tumor spread into the perineural space from surrounding or adjacent tumor was seen. Proximal large cranial nerves showed epineural involvement in 3.9% in areas with large tumor bulk, extensive PNI, and intraneural invasion. ConclusionPerineural tumor spread in cutaneous SCCHN was contiguous and no skip lesions were evident in nerve specimens assessed in this series. Spread beyond cranial nerve perineurium was uncommon, reflecting its multilayer barrier function at this level. These findings may have treatment implications. (c) 2013 Wiley Periodicals, Inc. Head Neck 36: 1611-1618, 2014
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