期刊
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
卷 32, 期 2, 页码 191-198出版社
JOHN WILEY & SONS INC
DOI: 10.1002/hed.21167
关键词
oral tongue cancer; elective neck treatment; radiotherapy; squamous cell carcinoma
Background. A prospective study was undertaken to evaluate a policy of selective, single-modality elective neck treatment in T1-2, node-negative oral tongue squamous cell carcinoma. Methods. Where the primary tumor showed 1 of the 4 key pathological criteria (greater than 7 mm of muscle invasion, less than 5 mm of resection margin, perineural or lymphovascular invasion), radiotherapy was delivered to the primary site and the at-risk undissected neck. Otherwise patients underwent ipsilateral neck dissection within 4 weeks of initial resection. Prospective quality of life assessments were performed. Results. The study was closed after accrual of 25 patients, because the high locoregionai recurrence rate met early stopping criteria. With a median follow-up of 3.4 years, the locoregional recurrence rate was 23%. The 4-year overall and disease-free survival rates were 71% and 64%, respectively. Conclusion. The poor disease-free survival reflects the need for better prognostic markers and more aggressive treatment in these patients. (C) 2009 Wiley Periodicals, Inc. Head Neck 32: 191-198, 2010
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