期刊
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
卷 30, 期 2, 页码 222-229出版社
JOHN WILEY & SONS INC
DOI: 10.1002/hed.20681
关键词
surgery; proton beam radiation; skull base; sinonasal tumors; outcomes
资金
- NCI NIH HHS [P01-CA-21239] Funding Source: Medline
Background. The relative importance of surgery within multimodality regimens commonly used to treat advanced sinonasal malignancies remains unknown. Methods. One hundred two patients with locally advanced sinonasal cancers treated with proton beam radiation therapy with or without surgery were retrospectively reviewed. Extent of surgery and outcome variables of local control, disease-free survival, and overall survival were evaluated. Patterns of failure were also assessed. Results. Extent of surgery correlated with disease-free survival and overall survival rates. Local control rate, however, was independent of the degree of surgical resection achieved. Overall, treatment failure most commonly resulted from distant metastases, which occurred in 30% of patients and also correlated with extent of surgical resection. Tumor type-specific outcomes reveal differences associated with the extent of surgery achieved. Conclusion. High-dose radiotherapy with proton beam resulted in excellent local control rates in patients with locally advanced sinonasal cancer, irrespective of the extent of surgery. Complete resection, however, was predictive of improved disease-free survival and decreased rate of distant metastasis. (C)2007 Wiley Periodicals, Inc.
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