期刊
HAMOSTASEOLOGIE
卷 33, 期 1, 页码 17-20出版社
GEORG THIEME VERLAG KG
DOI: 10.5482/HAMO-13-01-0002
关键词
MicroRNAs
类别
MicroRNAs (miRNAs), highly conserved, short (approx. 22 nucleotides) non-coding RNAs, exhibit a fine-tune control over gene expression by complementary sequence binding and translational repression of protein coding mRNA transcripts. Recently, the role of miRNAs has been increasingly investigated in various physiological or pathophysiological events. Circulating platelets are crucial for coagulation physiology to maintain haemostatic balance and are involved in various pathologies such as atherosclerosis and thrombosis. Anucleate platelets lack genomic DNA but inherit diverse array of functional coding or non-coding RNAs and translational machinery from their parent cells - megakaryocytes enabling activated platelets to synthesize proteins which suggests the possibility of post transcriptional gene regulation 1 in platelets. Expression of functionally active miRNAs in platelets changes during platelet activation indicating a role in platelet biology. Here, we present a review on recently identified platelet miRNAs and their role in platelet physiology that is essential for main, taining haemostasis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据