期刊
HAMOSTASEOLOGIE
卷 34, 期 1, 页码 63-71出版社
GEORG THIEME VERLAG KG
DOI: 10.5482/HAMO-13-09-0050
关键词
Atherosclerosis; inflammation; mechanisms; inflammatory cells; clinical trials
类别
Throughout the last two decades inflammation has been recognized as the central mechanism underlying atherogenesis. A multitude of basic science work demonstrates the pivotal role of inflammatory processes during every step of atherosclerotic plaque formation: From initiation via propagation to complication. This review describes some of the key mechanisms involved with a particular focus on the diverse group of inflammatory cells and their subsets that distinctly contribute to atherogenic and anti-atherogenic phenomena. Furthermore, we summarize the controlling action of a tight network of co-stimulatory molecules and cytokines orchestrating the inflammatory and anti-inflammatory effector functions. Finally, the current status of clinical trials evaluating anti-inflammatory/immune-modulatory treatment strategies is summarized and an outlook for future therapeutic implications is provided.
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