期刊
ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
卷 124, 期 10, 页码 820-823出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0003489415583330
关键词
lymphatic malformation; macroglossia; sirolimus
Objective: To evaluate the effectiveness and safety of sirolimus therapy in a child with macroglossia due to lymphatic malformation. Methods: Sirolimus treatment was applied to the patient with an initial dosing of 0.8 mg/m(2) per dose, administered orally, twice daily at approximately 12-hour intervals. Results: After 9 months of sirolimus therapy, there was a nearly complete resolution of lymphatic malformation. The last evaluation was performed 6 months after withdrawal of treatment, and the lesion had almost completely resolved. Conclusion: This article presents a novel approach to the treatment of lymphatic malformation of the tongue using sirolimus, which appears to be safe and effective for the management of complex cases.
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