Tardigrades : Natures' Survivor and Biomedical Pioneer

作者

Aniket Singh¹ , Poushali Roy¹ , Tamali Das¹ , Neelabh Datta¹

1. Asutosh College (Affiliated to University of Calcutta)

会议/活动

Modern Trends in Microbiology Chapter XX, October 2023 (Kolkata, India)

海报摘要

Meet tardigrades, the ultimate superheroes of the microscopic world! These tiny "water bears" can withstand extreme conditions like dehydration, freezing, and radiation. They achieve this by entering a death-like state called cryptobiosis, expelling water and curling up into a dehydrated tun. Scientists are fascinated by their radiation tolerance and stress-resistant genes, which have already been used to enhance human cells' resistance to radiation. The tardigrade genome holds promise for cancer research, genome integrity, and discovering new molecules for biomedical applications. Proteins like Dsup and CAHS are already showing potential for mitigating DNA damage and oxidative stress. Who knew these tiny creatures could have such a big impact on human medicine?

关键词

Tardigrades, Biomedical application, Intrinsically disordered protein, Drug delivery

研究领域

Biological Sciences, Microbiology

参考文献

1. Hashimoto, T., Horikawa, D. D., Saito, Y., Kuwahara, H., Kozuka-Hata, H., Shin-I, T., Minakuchi, Y., Ohishi, K., Motoyama, A., Aizu, T., Enomoto, A., Kondo, K., Tanaka, S., Hara, Y., Koshikawa, S., Sagara, H., Miura, T., Yokobori, S. I., Miyagawa, K., Suzuki, Y., … Kunieda, T. (2016). Extremotolerant tardigrade genome and improved radiotolerance of human cultured cells by tardigrade-unique protein. Nature communications, 7, 12808. https://doi.org/10.1038/ncomms12808
2. Hesgrove, C., Boothby, T.C. (2020). The biology of tardigrade disordered proteins in extreme stress tolerance. Cell Commun Signal 18, 178. https://doi.org/10.1186/s12964-020-00670-2
3. Kasianchuk, N., Rzymski, P., & Kaczmarek, Ł. (2023). The biomedical potential of tardigrade proteins: A review. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 158, 114063. https://doi.org/10.1016/j.biopha.2022.114063
4. Neves, R. C., Hvidepil, L. K. B., Sørensen-Hygum, T. L., Stuart, R. M., & Møbjerg, N. (2020). Thermotolerance experiments on active and desiccated states of Ramazzottius varieornatus emphasize that tardigrades are sensitive to high temperatures. Scientific reports, 10(1), 94

基金

暂无数据

补充材料

暂无数据

附加信息

利益冲突

No competing interests were disclosed.

数据可用性声明

Data sharing not applicable to this poster as no datasets were generated or analyzed during the current study.

知识共享许可协议

Copyright © 2024 Singh et al. This is an open access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.