Gut Microbial Dysbiosis and Its Association with Euthyroid Thyroid Cancer

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Hafiz Muhammad Ishaq¹

Department of Pathobiology & biomedical Sciences, MNS- University of Agriculture Multan, Pakistan

海报摘要: Thyroid cancer in humans has a fast-growing prevalence, with the most common lethal endocrine malignancy for unknown reasons. The current study was aimed to perform qualitative and quantitative investigation and characterization of the gut bacterial composition of euthyroid thyroid cancer patients. The fecal samples were collected from 16 euthyroid thyroid cancer patients and 10 from healthy subjects. qPCR and PCR-DGGE, High-throughput sequencing of V3+V4 region of 16S rRNA gene was performed on fecal samples. It also observed the significantly elevated richness of Escherichia-Shigella, Akkermansia [Eubacterium]_coprostanoligenes, Dorea, Subdoligranulum, and Ruminococcus_2 genera, while significantly declined genera of the patient group were Prevotella_9, Bacteroides and Klebsiella. The species-level, significant raised level of Escherichia coli in euthyroid thyroid cancer. Thus, this study reveals that euthyroid thyroid cancer patients have significant gut microbial dysbiosis. Moreover, Therefore, the current study may propose new approaches to understand the disease pathways, mechanisms, and treatment of thyroid cancer patients.

关键词: Euthyroid thyroid cancer, DGGE, High-throughput sequencing, Characterization, Gut microbiota

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数据可用性声明: The datasets generated during and / or analyzed during the current study are available from the corresponding author on reasonable request.

知识共享许可协议: Copyright © 2024 Ishaq. This is an open access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.