The Gut-Brain-Axis: A Positive Relationship between Gut Microbial Dysbiosis and Glioblastoma Brain Tumour

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作者

Hafiz Muhammad Ishaq¹

1. Department of Pathobiology & Biomedical Sciences, MNS University of Agriculture Multan, Pakistan

会议/活动

PREEF, July 2024 (虚拟会议)

海报摘要

The glioblastoma brain tumour (GBM) is the most aggressive and treatment-resistant malignancy. However, the gut-brain axis is crucial for the growth and stimulation of the CNS. Fecal samples were collected from 15 healthy volunteers and 25 GBM patients. To delve into the microbial content, we employed PCR-DGGE targeting the V3 region of the 16S rRNA gene. qPCR was also conducted to quantify the crucial intestinal bacteria. High-throughput sequencing targeting the V3+V4 region of the 16S rRNA gene was performed. Delving into genera statistics, a substantial increase in the abundance of Parasutterella, Escherichia-Shigella, and Bacteroides in GBM group compared to the control group. Furthermore, species results revealed a significant increase of Bacteroides vulgatus and Escherichia coli in the GBM group. Thus, GBM patients have significant gut microbial dysbiosis. So, the current research opens up new strategies to comprehend the disease mechanisms, pathways, and treatment of GBM patients.

关键词

GBM, DGGE, High-throughput sequencing, Gut Bacteria, Dysbiosis

研究领域

Microbiology

参考文献

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基金

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补充材料

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附加信息

利益冲突

No competing interests were disclosed.

数据可用性声明

Data sharing not applicable to this poster as no datasets were generated or analyzed during the current study.

知识共享许可协议

Copyright © 2024 Ishaq. This is an open access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.