Synthesis and characterization of L-lysine polyurethane (LPU) nanoparticles for drug delivery system

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作者

Soojeong Choi¹ , Seoeun Oh¹ , Ildoo Chung¹

1. Pusan National University

会议/活动

8th Asian Symposium on Advanced Materials ASAM-8, July 2023 (Novosibirsk, Russian Federation)

海报摘要

To obtain biodegradable biomaterial for matrix of drug delivery, L-lysine polyurethane(LPU) was designed using the biodegradable triblock oligomer polylactide-poly(ethylene glycol)-polylactide(PLA-PEG-PLA) as a soft segment, 1,6-hexamethylene diisocyanate(HMDI) as a hard segment and L-lysine ethyl ester(LEE) as a chain extender. PLA-PEG-PLA was synthesized by ring opening polymerization(ROP) of lactide monomer onto poly(ethylene glycol) core and stannous octoate as a catalyst. LEE was synthesized by esterification of L-lysine with ethanol using thionyl chloride as a catalyst. LPU nanoparticles were fabricated by using water-in-oil-in-water double emulsion technique.

关键词

Drug delivery system, Biodegradable, Doublbe emulsion method, Ring opening polymerization, Polyurethane

研究领域

Bioengineering, Chemical Engineering, Material Sciences

参考文献

1. Soo-Yong Park, Yang H. Yun, Bum-Joon Park, Hyung-Il Seo, Ildoo Chung, Fabrication and Biological Activities of Plasmid DNA Gene Carrier Nanoparticles Based on Biodegradable L-Tyrosine Polyurethane, Pharmaceuticals, 2022, vol 15, 17-33
2. Soo-Yong Park, Jiin Kang, Ji-Young Yoon, Ildoo Chung, Synthesis and Characterization of Polyfumarateurethane Nanoparticles for Sustained Release of Bupivacaine, Pharmaceutics, 2020, vol 12, 281-293

基金

1. the National Research Foundation of Korea (NRF) (No. 2022R1I1A30535561162182065300101)

补充材料

暂无数据

附加信息

利益冲突

No competing interests were disclosed.

数据可用性声明

The datasets generated during and / or analyzed during the current study are available from the corresponding author on reasonable request.

知识共享许可协议

Copyright © 2023 Choi et al. This is an open access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.