Neonatal aluminium and cadmium co-exposures induce behavioural deficits and oxido-inflammatory imbalance in the mice brain.

作者

Patrick Chukwuyenum Ichipi-Ifukor¹ , Joseph Chuks Mordi² , Benneth Ben-Azu³ , Samuel Ogheneovo Asagba¹ , Fidelis Achuba¹

1. Department of Biochemistry, Delta State University, Abraka
2. Department of Medical Biochemistry, Delta State University, Abraka
3. Department of Pharmacology and Therapeutics, Delta State University, Abraka

会议/活动

9th National Scientific Conference of the Neuroscience Society Of Nigeria, August 2022 (Ibadan, Nigeria)

海报摘要

We investigated the effect of early cadmium and aluminium co-exposures in neonatal mice. The study which comprised four groups of Control: A; AlCl3:B; CdCl2:C and AlCl3+CdCl2 :D. Weekly intraperitoneal treatment commenced on postnatal day 7 and lasted till postnatal day 35. Following behavioural phenotyping, on postnatal day 55-57, animals were sacrificed on PD 58 and brains were harvested. Brain regions (prefrontal cortex (PFC), stratum (ST) and hippocampus (HP)) were processed for oxido-inflammatory indices. Data was expressed as mean ± SD. P<0.05 was considered as statistically significant using a one-way ANOVA followed by Bonferroni multiple comparison test. Our findings suggests that neonatal co-exposures of aluminium and cadmium induced behavioural modifications relative to hyper locomotion and memory deficits found in several neurodevelopmental pathologies. These behavioural modifications may have occurred in response to altered oxido-inflammatory balance in the mice brain.

关键词

Cadmium, Aluminium, Oxido-inflammatory, Neonatal-exposure, Behavioral deficit

研究领域

Biological Sciences, Toxicology, Neuroscience, Biochemistry

参考文献

1. Weidenhamer, J. D., Fitzpatrick, M. P., Biro, A. M., Kobunski, P. A., Hudson, M. R., Corbin, R. W., & Gottesfeld, P. (2017). Metal exposures from aluminum cookware: An unrecognized public health risk in developing countries. Science of the Total Environment, 579:805-813.
2. Ichipi-Ifukor, P.C., Asagba, S.O., Nwose, C., Mordi, J.C. and Oyem, J.C (2022). Palm oil extracts protected against cadmium chloride poisoning via inhibition of oxidative stress in rats. Bulletin of National Research Centre, 46:5
3. Fermo, P., Soddu, G., Miani, A. and Comite, V. (2020). Quantification of the aluminum content leached into foods baked using aluminum foil. International Journal of Environmental Research and Public Health, 17(22), 8357.
4. Ben-Azu, B., Aderibigbe, A. O., Ajayi, A. M., Eneni, A. E. O., Omogbiya, I. A., Owoeye, O., ... and Iwalewa, E. O. (2019). Morin decreases cortical pyramidal neuron degeneration via inhibition of neuroinflammation in mouse model of schizophrenia. International Immunopharmacology, 70:338-353.

基金

暂无数据

补充材料

暂无数据

附加信息

利益冲突

No competing interests were disclosed.

数据可用性声明

The datasets generated during and / or analyzed during the current study are available from the corresponding author on reasonable request.

知识共享许可协议

Copyright © 2023 Ichipi-Ifukor et al. This is an open access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.