Neuropathic pain correction method using mesenchymal stem cells and cannabinoid receptor CB2 stimulation.

作者

Anna-Maria V. Yerofeyeva¹ , Sergey V. Pinchuk² , Svetlana N. Rjabceva¹ , Alla Yu. Molchanova¹

1. Institute of Physiology NAS of Belarus
2. Institute of Biophysics and Cell Engineering NAS of Belarus

会议/活动

International Scientific Conference "Fundamental and Applied Sciences to Medicine", October 2022 (Minsk, Belarus)

海报摘要

Peripheral neuropathic pain is chronic pain due to damage or dysfunction of the peripheral nervous system. Mesenchymal stem cell (MSCs) transplantation is positioned as an effective treatment for neuropathic pain. Cannabinoid receptors CB1 and CB2 may be involved in MSC's actions, and their stimulation will possibly improve the effects of MSCs. In an in vivo experiment, we determined the mode of ADMSCs administration with the most pronounced and long-lasting analgesic effect in rats with neuropathic pain (NP). We have found an increase in the analgesic effect of ADMSCs through additional action on cannabinoid CB2 receptors, activated either on stem cells or in the area of sciatic nerve injury.

关键词

Mesenchymal stem cells, Neuropathic pain, Cannabioid receptor, Catwalk

研究领域

Anatomy and Physiology, Neuroscience, Molecular and Cellular Biosciences

参考文献

1. Bouhassira D. Rev Neurol, 2019;175,1-2: 16-25.
2. Rull T. et al. J Tissue Eng Regen Med, 2021;15: 88-98.
3. Yerofeyeva A.-M. et al. Surgery News, 2021; 29, 5: 527-534.

基金

暂无数据

补充材料

暂无数据

附加信息

利益冲突

No competing interests were disclosed.

数据可用性声明

The datasets generated during and / or analyzed during the current study are available from the corresponding author on reasonable request.

知识共享许可协议

Copyright © 2023 Yerofeyeva et al. This is an open access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.