139 次浏览
·
83 次下载
·
★★★★★ 5.0
A side-chain tripeptide based PEGylated block copolymer: a potential drug candidate in Alzheimer’s disease translational therapeutics
发表日期 March 14, 2023 (DOI: https://doi.org/10.54985/peeref.2303p6424311)
未经同行评议
-
作者
-
Sutapa Som Chaudhury1 , Jaya Sil1 , Sabyashachi Mishra2 , Chitrangada Das Mukhopadhyay1
- Indian Institute of Engineering Science and Technology, Shibpur
- Indian Institute of Technology, Kharagpur
-
会议/活动
- 4th IBRO/APRC Chandigarh Associate Neuroscience School, November 2019 (Chandigarh, India)
-
海报摘要
- Despite a 100 years of research in Alzheimer’s disease (AD), there is no therapeutic measure available till date for AD. The researchers here have designed and synthesized a PEGylated, side-chain tripeptide (leu-val-phe) based block copolymer targeting anti- aggregation of misfolded amyloid beta peptide (Aβ1-42). The block copolymer was assessed via different in vitro and in silico techniques e.g., thioflavin T (ThT) assay, dynamic light scattering (DLS) analyses, atomic force microscopy (AFM), electron microscopy, and molecular dynamic (MD) simulation techniques. A significant demolition of the characteristic β- sheet structure of growing Aβ42 fibril chain in presence of the inhibitor was observed through their experiments. Also, they deciphered the drug mechanism of action as a competitive inhibition between the hydrophobic core region of Aβ42 and the block copolymer itself. Thus, the researchers showed the PEGylated block copolymer as a promising drug candidate of AD.
-
关键词
- Alzheimer's disease, Amyloid beta peptide, Inhibitor, Fibrillization, Peptidomimetics, MD simulation
-
研究领域
- Neuroscience, Molecular and Cellular Biosciences, Biological Sciences
-
参考文献
-
- S Som Chaudhury, A Sannigrahi, M Nandi, V K Mishra, P De, K Chattopadhyay, S Mishra, J Sil and C Das Mukhopadhyay, Molecular Neurobiology 56, 2019, 6551–6565.
- H Xu, J Park, W Wu, A Malagon, L Wang, E Vargas, A Wikramanayake, K N Houk and R M Leblanc, Chemical science 8, 2017, 2003-2009.
- C D Mukhopadhyay, B Ruidas and S S Chaudhury, Int J Neurorehabilitation 4, 2017, 2376-0281.
- S Hadas, R Chen, I Grinberg and S Margel, Biomacromolecules 13, 2012, 2662-2670.
- B Sergey O, E V Bovina and A A Ustyugov, Medicinal research reviews 37, 2017, 1186-1225.
- J L Cummings, T Morstorf and Kate Zhong, Alzheimer's research & therapy 6, 2014, 37.
- S Lon S, F Mangialasche, N Andreasen, H Feldman, E Giacobini, R Jones and V Mantua, Journal of internal medicine 275, 2014, 251-283.
-
基金
- 暂无数据
-
附加信息
-
- 利益冲突
- No competing interests were disclosed.
- 数据可用性声明
- The datasets generated during and / or analyzed during the current study are available from the corresponding author on reasonable request.
- 知识共享许可协议
- Copyright © 2023 Som Chaudhury et al. This is an open access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
分享
评分
引用
Som Chaudhury, S., Sil, J., Mishra, S., Das Mukhopadhyay, C. A side-chain tripeptide based PEGylated block copolymer: a potential drug candidate in Alzheimer’s disease translational therapeutics [not peer reviewed]. Peeref 2023 (poster).
复制引文
For conference organizers
Utilize the Peeref poster repository to provide free poster publishing for your next event.
Download our convenient portal entry point and include it in your event page.
Get conference accessAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started