A possible role of arsenic exposure in diabetes and obesity

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作者

Abinaya Girisankar Prema¹ , Iyshwarya Bhaskar Kalarani¹ , Ramakrishnan Veerabathiran¹

1. Chettinad Academy of Research and Education

会议/活动

CODI Controversies inObesity & Diabetes, October 2022 (虚拟会议)

海报摘要

In the modern world, obesity and diabetes are the most prevalent diseases. Around 39% of adults worldwide are obese and approximately 422 million are diabetics, according to the WHO. A complex disease, obesity is caused by body fat accumulation and a body mass index of 30 kg/m2 or higher. People who consume too much energy store the excess energy as glycogen in their adipose tissues, resulting in insulin resistance. By generating free radicals and inhibiting anti- oxidants, it elevates reactive oxygen species and causes oxidative stress. A major role that melatonin plays as a therapy for arsenic-induced diabetes is as a free radical scavenger. Pineal glands release melatonin, which has a lipophilic nature and can pass through all intracellular organs, preventing lipid peroxidation, reducing oxidative stress, and preventing cell death. Researchers are testing microRNA regulators as well as resveratrol to see if they can control arsenic-induced diabetes.

关键词

Obesity, Diabetes, Arsenic, Insulin resistance, Melatonin, Oxidative stress

研究领域

Genetics

参考文献

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基金

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附加信息

利益冲突

No competing interests were disclosed.

数据可用性声明

Data sharing not applicable to this poster as no datasets were generated or analyzed during the current study.

知识共享许可协议

Copyright © 2022 Girisankar Prema et al. This is an open access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.