Stem cell technology to cure age-related macular degeneration (AMD)

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作者

Kruthica Jaganathan Geethalakshmi¹ , Iyshwarya Bhaskar Kalarani¹ , Ramakrishnan Veerabathiran¹

1. Chettinad Academy of Research and Education

会议/活动

Chettinad Academy of Research and Education, October 2022 (Chettinad Health City, India)

海报摘要

Age-related macular degeneration (AMD) is a disorder that affects the retinal pigment epithelium which is a multifunctional monolayer of hexagonal cells at the back of the eye. The loss of retinal pigment epithelium (RPE) cells in age-related macular degeneration (AMD) causes the demise of photoreceptors and everlasting blindness, RPE cell transplantation strives to cure or reverse vision loss by preventing the death of photoreceptor cells and the most prominent application is stem cell treatment in regenerative medicine. According to initial reports from clinical trials, transplanting RPE cells obtained from HPSCs can allow AMD patients to vision clear, as a proof-of-concept, RPE cell transplantation for treating other retinal degenerative diseases such as AMD, has long been demonstrated in human and animal studies involving primary RPE cells, although recent studies have concentrated on the transplantation of RPE cells made from human pluripotent stem cells (HPSC).

关键词

Macular degeneration, Photoreceptors, Retina, Stem cells, Genetics

研究领域

Genetics

参考文献

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基金

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补充材料

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附加信息

利益冲突

No competing interests were disclosed.

数据可用性声明

Data sharing not applicable to this poster as no datasets were generated or analyzed during the current study.

知识共享许可协议

Copyright © 2022 Jaganathan Geethalakshmi et al. This is an open access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.