Study of genetic polymorphisms in autism spectrum disorder

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作者

Iyshwarya Bhaskar Kalarani¹ , Ramakrishnan Veerabathiran¹

1. Chettinad Academy of Research and Education

会议/活动

Chettinad Academy of Research and Education, March 2022 (Chennai, India)

海报摘要

Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by stereotyped behavior and poor social interaction. There are approximately 52 million people worldwide who suffer from this disease. Candidate genes associated with ASD are CHD8, SHANK3, SLC6A4, RELN, DISC1, and ITGB3. It is known that a number of prenatal risk factors increase the chances of developing autism and other neurodevelopmental disorders in children. Some genetic mutations and modifications may serve as useful biological markers, risk indicators, and therapeutic targets for diseases because of recent technological advances. To understand disease development better, more studies are needed on environmental variables. The clinical evidence supporting ASD's function is limited at present. The prevailing evidence suggests that many new candidate genes for ASD may be associated with its etiology. Therefore, they may be useful in developing an early diagnostic marker.

关键词

Autism spectrum disorder, Mechanism, Pathogenesis, Genetic polymorphism

研究领域

Genetics

参考文献

1. Alotaibi, M., & Ramzan, K. (2020). A de novo variant of CHD8 in a patient with autism spectrum disorder. Discoveries, 8(1), e107.
2. Frye, R. E., Vassall, S., Kaur, G., Lewis, C., Karim, M., & Rossignol, D. (2019). Emerging biomarkers in autism spectrum disorder: a systematic review. Annals of Translational Medicine, 7(23).
3. Rylaarsdam, L., & Guemez-Gamboa, A. (2019). Genetic causes and modifers of autism spectrum disorder. Frontiers in Cellular Neuroscience, 13, 385.

基金

暂无数据

补充材料

暂无数据

附加信息

利益冲突

No competing interests were disclosed.

数据可用性声明

Data sharing not applicable to this poster as no datasets were generated or analyzed during the current study.

知识共享许可协议

Copyright © 2022 Bhaskar Kalarani et al. This is an open access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.