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LSD, Afterglow and Hangover: Increased Episodic Memory and Verbal Fluency, Decreased Cognitive Flexibility
发表日期 September 30, 2022 (DOI: https://doi.org/10.54985/peeref.2209p2741243)
未经同行评议
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作者
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Isabel Wießner1 , Rodolfo Olivieri1 , Marcelo Falchi1 , Fernanda Palhano-Fontes2 , Lucas Oliveira Maia1 , Amanda Feilding3 , Draulio Araujo2 , Sidarta Ribeiro2 , Luís Fernando Tófoli1
- School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil
- Brain Institute, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil
- The Beckley Foundation, Beckley Park, Oxford, United Kingdom
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会议/活动
- Interdisciplinary Conference on Psychedelic Research, September 2022 (Haarlem, Netherlands)
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海报摘要
- Psychedelics acutely impair cognition and might sub-acutely improve it in ceremonial settings. In this light, we applied a randomized, double-blind, placebo-controlled, crossover study with 24 healthy volunteers receiving 50μg lysergic acid diethylamide (LSD) or inactive placebo. Cognition was measured 24 hours post-administration (Rey-Osterrieth Complex Figure; Object-Location Memory Task; Rey Auditory-Verbal Learning Test; verbal fluency; design fluency; Wisconsin Card Sorting Test; Trail Making Test; Stroop Task; Block Design Test). The results show that when compared to placebo and corrected for Body Mass Index and abstinence period from psychedelics, LSD sub-acutely improved visuospatial memory (ROCF, OLMT) and phonological verbal fluency and impaired cognitive flexibility (WCST). In conclusion, low-dose LSD moderately induced both “afterglow” and “hangover”. The improvements in visuospatial memory and phonological fluency suggest that LSD-assisted therapy should be explored as a novel treatment perspective in conditions involving memory and language declines such as brain injury, stroke or dementia.
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关键词
- Sub-acute LSD effects, Psycholytic dose, Visuospatial memory, Phonological verbal fluency, Cognitive flexibility, Executive functions
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研究领域
- Neuroscience, Psychology and Behavioral Sciences
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参考文献
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- Barrett FS, Carbonaro TM, Hurwitz E, Johnson MW, Griffiths RR. Double-blind comparison of the two hallucinogens psilocybin and dextromethorphan: effects on cognition. Psychopharmacology (Berl). 2018;235(10):2915–27.
- Pokorny T, Duerler P, Seifritz E, Vollenweider FX, Preller KH. LSD acutely impairs working memory, executive functions, and cognitive flexibility, but not risk-based decision-making. Psychol Med. 2019;1–10.
- Preller KH, Vollenweider FX. Phenomenology, Structure, and Dynamic of Psychedelic States. In: Behavioral neurobiology of psychedelic drugs [Internet]. Springer Berlin Heidelberg; 2016. p. 221–56.
- Murphy-Beiner A, Soar K. Ayahuasca’s ‘afterglow’: improved mindfulness and cognitive flexibility in ayahuasca drinkers. Psychopharmacology (Berl). 2020;237(4):1161–9.
- Uthaug MV, van Oorsouw K, Kuypers KPC, van Boxtel M, Broers NJ, Mason NL, et al. Sub-acute and long-term effects of ayahuasca on affect and cognitive thinking style and their association with ego dissolution. Psychopharmacology (Berl). 2018;235(10):2979–89.
- Uthaug MV, Lancelotta R, van Oorsouw K, Kuypers KPC, Mason NL, Rak J, et al. A single inhalation of vapor from dried toad secretion containing 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in a naturalistic setting is related to sustained enhancement of satisfaction with life, mindfulness-related capacities, and a decrement of psyc. Psychopharmacology (Berl). 2019;236(9):2653–66.
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基金
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- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) (No. Finance Code 001)
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) (No. grants 308775/2015-5 and 408145/2016-1)
- Sao Paulo Research Foundation (No. grants 2013/07699-0 (Neuromathematics) and 2014/10068-4)
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补充材料
- 暂无数据
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附加信息
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- 利益冲突
- SR declares the following patent application as a competing interest: a) Patent applicants (The Beckley Foundation, Universidade Federal do Rio Grande do Norte); b) Name of inventors: Not yet listed; c) Application number: 1 911 024.6; d) Status of application: pending.
- 数据可用性声明
- The datasets generated during and / or analyzed during the current study are available from the corresponding author on reasonable request.
- 知识共享许可协议
- Copyright © 2022 Wießner et al. This is an open access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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引用
Wießner, I., Olivieri, R., Falchi, M., Palhano-Fontes, F., Oliveira Maia, L., Feilding, A., Araujo, D., Ribeiro, S., Tófoli, L. LSD, Afterglow and Hangover: Increased Episodic Memory and Verbal Fluency, Decreased Cognitive Flexibility [not peer reviewed]. Peeref 2022 (poster).
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