ATP-sensitive K+ Channel Contribution to Skeletal Muscle Vascular Control in Rats During High Speed Running

作者

Clark Holdsworth¹ , Scott Ferguson¹ , Trenton Colburn¹ , Sue Hageman¹ , David Poole¹ , Timothy Musch¹

1. Kansas State University

会议/活动

American College of Sports Medicine Annual Meeting, May 2015 (San Diego, CA, United States)

海报摘要

The ATP-sensitive K+ (KATP) channel is a class of inward rectifier K+ channels that can link local O2 availability to vasomotor tone across exercise-induced metabolic transients. Thus, the KATP channel contribution to vascular control is expected to be related to the magnitude of metabolic demand during exercise in vivo. The aim of this investigation was to test the hypothesis that KATP channel blockade via glibenclamide (GLI) would decrease exercising hindlimb skeletal muscle blood flow (BF) and vascular conductance (VC) in a speed-dependent manner during treadmill exercise at 40 and 60 m·min-1. In 13 adult male Sprague Dawley rats mean arterial pressure (MAP), blood [lactate], and hindlimb muscle BF (radiolabelled microspheres) was determined during treadmill exercise (5% incline) at 40 (n = 6) or 60 m·min-1 (n = 7) under control (CON) and GLI conditions (2.5 mg·kg-1, i.a). KATP channel function does not differentially alter total hindlimb skeletal muscle BF and VC at 40 and 60 m·min-1 in rats. However, the magnitude of the decrease in VC (24% and 33%, respectively) is greater than that previously demonstrated at 20 m·min-1 (20%) and the fiber-type dependent effects persisted despite the presumably increased recruitment of type IIb/dx fibers at higher speeds.

关键词

exercise hyperemia, vascular control, metabolic coupling

研究领域

Anatomy and Physiology

参考文献

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基金

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补充材料

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附加信息

利益冲突

No competing interests were disclosed.

数据可用性声明

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

知识共享许可协议

Copyright © 2022 Holdsworth et al. This is an open access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.