The study highlights the urgent need to address plastic pollution due to its extensive environmental and health impacts and proposes an innovative microbial approach to mitigate these effects.
The FDA's Notice of Funding Opportunity, issued by its Center for Veterinary Medicine, invites grant applications for the development of new animal drugs for minor uses in major species or minor species, with grants aimed at supporting safety and effectiveness testing for FDA approval. Eligible applicants must have an Investigational New Animal Drug file with the FDA and a minor use or species designation, and the FDA's Office of New Animal Drug Evaluation must approve the study protocol before grant application submission.
The USAID's Broad Agency Announcement (BAA) invites diverse organizations to collaborate on innovative health interventions aimed at reducing disease and mortality rates in low-and-middle-income countries. This initiative emphasizes co-creation, co-design, and co-investment, fostering efficient, inclusive partnerships to develop and scale effective global health solutions.
The authors found that older adults who have sleep patterns resembling those of younger people generally exhibit better physical and cognitive health, compared to their peers with age-typical disrupted sleep. The study, which analyzed brain activity and sleep characteristics of participants aged 54 to 96, suggests that modifying sleep patterns in older individuals could potentially improve their health.
In embryonic development, some endothelial cells lining blood vessels transform into blood-producing stem cells. Karen Hirschi and Stefania Nicoli at Yale University, and their team, studied this process in zebrafish. They found that specific sugars on the endothelial cells' surface trigger a genetic switch, turning these cells into blood stem cells. This discovery could lead to new methods for creating blood stem cells in the lab, offering potential treatments for diseases like leukemia.
Very interesting article!!! A contagious cancer, originally found in bay mussels, has spread across oceans and species barriers, now affecting blue mussels in Europe and Chilean mussels in South America. The authors discovered that these transmissible tumours, likely spread through international shipping, originated in bay mussels and have genetically similar markers in the affected species, causing mass die-offs in these mussel populations.
Very interesting article to read!!! The authors here have developed a method for 3D printing intricate glass objects without needing to heat the glass to high temperatures. They created a special ink containing glass precursors and light-responsive compounds, which is solidified by light in a standard 3D printer and then processed through baking and air removal to transform from a porous material into transparent glass.
Michelle Monje and her team at Stanford University discovered that a combination of panobinostat and marizomib shows promise against diffuse midline gliomas, a fatal nervous-system cancer primarily affecting children. After testing over 2,700 single compounds and more than 9,000 drug combinations on patient-derived tumor cell cultures, this combination notably increased survival in mice models of the disease.
A new RNA-based test developed by Deborah Hung and her team at the Broad Institute rapidly identifies antibiotic-resistant bacteria within a few hours, much faster than traditional methods. This test, which uses machine learning, detects specific RNA molecules produced by bacteria when exposed to antibiotics, distinguishing resistant strains from sensitive ones. In a trial, the test accurately identified antibiotic resistance in 71 of 72 samples of Klebsiella pneumoniae and Escherichia coli in less than 4 hours. This innovation could significantly improve the response to the growing issue of drug-resistant infections, which cause at least 700,000 deaths annually according to the World Health Organization.
Gut nerve cells, specifically nociceptors, are key in preventing symptoms like diarrhea and vomiting from Salmonella infections. Research by Isaac Chiu at Harvard Medical School found that mice lacking these nociceptors had significantly more Salmonella bacteria in their gut compared to normal mice. Nociceptors not only reduce the number of cells that Salmonella can infect but also help maintain beneficial gut bacteria. This discovery suggests that targeting nociceptors could lead to new treatments for infectious and inflammatory diseases.
The proportion of home deaths in US rose from 24% to 31%, and deaths in hospice facilities also increased. The trend favouring death outside the hospital extends to people dying of a wide variety of diseases,
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