Article
Endocrinology & Metabolism
Xuezhong Xu, Fangyun Liang, Jinmei Chen, Feihong Chen, Lingyi Kong, Yipeng Ding
Summary: This study investigated the association of single nucleotide polymorphisms (SNPs) of FHL5 and LPA with diabetes mellitus (DM) risk in the Chinese population. The results suggest that the genetic polymorphisms of LPA may be associated with DM risk in the Chinese population.
Article
Urology & Nephrology
Ying Wang, Xiaoyang Yu, Xinfang Xie, Huixian Li, Wei Yang, Yu Liang, Wanhong Lu
Summary: This study investigates the clinical characteristics, pathological features, and outcomes of ANCA-positive SLE patients in northwest China. The results show that ANCA-positive SLE patients occur in older individuals compared to ANCA-negative SLE patients, but are younger than those with AAV. Patients with ANCA-positive LN have worse renal function and lower protein remission rates compared to ANCA-negative LN patients. ANCA titers should be regularly monitored in SLE patients, especially those with renal involvement.
Article
Urology & Nephrology
Qianqian Lou, Jianguang Gong, Binxian Ye, Rizhen Yu, Shuangshan Bu, Yiwen Li, Bin Zhu, Lina Shao
Summary: This retrospective cohort study assessed the incidence, risk factors, and prognosis of acute kidney injury (AKI) associated with anti-PD-1/PD-L1 antibodies. The study found that the use of diuretics, non-steroidal anti-inflammatory drugs (NSAIDs), lower hemoglobin level, and other types of chemotherapeutic drugs were independent risk factors for AKI. Therefore, it is necessary to closely monitor renal function, identify AKI early, improve anemia, and minimize the use of certain medications to reduce AKI occurrence.
Article
Urology & Nephrology
Xue Xing, Qing Li, Yi Yang, Yanan Wang, Xiaona Zhan, Cailin Zhang, Gang Xu, Fan He
Summary: By analyzing the clinical history, laboratory test indexes, and intraoperative ultrasound imaging data, the study investigated the application value of ultrasound-guided percutaneous transluminal angioplasty (UG-PTA) in the treatment of peripheral stenosis of autogenous arteriovenous fistula (AVF) and the factors affecting postoperative patency.
Article
Urology & Nephrology
Sihui Ma, Nan Pu, Juan Ma
Summary: This study compared the effects of high-flux hemodialysis (HFHD) and hemodiafiltration (HDF) on the survival of patients with end-stage kidney disease (ESKD) through a systematic review and meta-analysis. The results showed that HFHD has no significant impact on the overall mortality and cardiovascular mortality of ESKD patients compared to HDF, but it can reduce the risk of infection-related death.
Article
Urology & Nephrology
Xiao-Yan Zheng, Zhi-Hong Zhang, You-Ming Cheng, Qi Yang, Bing Xu, Bao-Chun Lai, Lan-Ting Huang
Summary: Objective of this study was to investigate factors affecting different subgroups of fatigue and the degree of fatigue in maintenance hemodialysis (MHD) patients. The study included 120 MHD patients and involved questionnaires, clinical data, bioimpedance spectroscopy, and ultrasound assessments. The prevalence of fatigue in participants was 83%, with different percentages for fatigue worsened, lessened, and undifferentiated by dialysis. Factors such as age, post-dialysis phosphorus level, and extracellular water / intracellular water (E/I) level were found to be associated with different subgroups of fatigue. Older patients were more prone to severe fatigue. In-depth studies are needed to clarify the pathogenesis of fatigue in MHD patients.
Article
Urology & Nephrology
Shilin Xu, Jun Ren, Yuping Yao, Danping Qin, Yan Liu, Xiaoshi Zhong, Rongshao Tan, Chunjie Jiang, Yun Liu, Wenxuan Chen
Summary: This cross-sectional study investigated the relationship between serum insulin-like growth factor-1 (IGF-1) levels and anemia in patients undergoing maintenance hemodialysis (MHD). The study found that patients with anemia had lower levels of serum IGF-1 and triglycerides, and higher intravenous iron supplementation. Multivariable analyses confirmed that lower serum IGF-1 levels and serum IGF-1 < 197.03 ng/ml were independently associated with anemia in MHD patients.
Article
Urology & Nephrology
Cristina Capusa, Ana-Maria Mehedinti, Liliana Barsan, Ana Stanciu, Andreea Calenic, Gabriel Mircescu
Summary: This study found that iron deficiency anemia (IDA) and anemia of chronic disorders (ACD) can coexist in patients with chronic kidney disease (CKD), and ferritin and transferrin saturation (TSAT) are useful markers for differentiating IDA-ACD from ACD, while hepcidin, a marker of iron in bone marrow macrophages, has limited utility.
Review
Endocrinology & Metabolism
Zhongyou Xia, Xueqin Fu, Jinze Li, Xinzhu Yuan, Ji Wu, Lingtong Tang
Summary: This study aimed to evaluate the feasibility of robot-assisted radical prostatectomy (RARP) in men aged over 75 years. The results showed that younger patients had better potency, but there were no significant differences in other perioperative, oncological, and functional outcomes between the age groups.
Article
Endocrinology & Metabolism
Aksam Yassin, Daniel Kelly, Joanne Nettleship, Raidh Talib, Raed M. Al-Zoubi, Omar M. Aboumarzouk, Bassam Albaba
Summary: Functional hypogonadism is a condition where testosterone levels are low, especially in older men. The severity of lower urinary tract symptoms (LUTS) in hypogonadal men can be categorized using the International Prostate Symptom Score (IPSS). Testosterone therapy (TTh) has shown potential in improving total IPSS in hypogonadal men, but concerns about urinary function have limited its use. A study on 1176 men with hypogonadism found that long-term TTh with testosterone undecanoate (TU) significantly improved IPSS categories, even in patients with severe symptoms at baseline, suggesting previous concerns may have been exaggerated.
Article
Endocrinology & Metabolism
Ji Eun Heo, Dong Gyun Kim, Jeong Woo Yoo, Kwang Suk Lee
Summary: A positive association between benign prostate hyperplasia (BPH)/lower urinary tract symptoms (LUTS) and metabolic syndrome (MetS) was found, with older age, higher IPSS values, higher prevalence rates of BPH and overactive bladder, higher triiodothyronine, and lower testosterone and sex-hormone binding globulin observed in individuals with MetS. The severity of LUTS significantly increased in individuals with MetS. Factors including TSH and atherosclerosis affected LUTS in individuals with MetS.
Letter
Endocrinology & Metabolism
Hasan Tahsin Gozdas, Tayibe Bal
Article
Urology & Nephrology
Yuancheng Zhao, Lijun Zhao, Yiting Wang, Junlin Zhang, Honghong Ren, Rui Zhang, Yucheng Wu, Yutong Zou, Nanwei Tong, Fang Liu
Summary: This study aimed to investigate the association between plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) and kidney outcomes in patients with type 2 diabetes mellitus and biopsy-proven diabetic kidney disease (DKD). The results showed that a higher level of plasma NT-proBNP was significantly associated with an increased risk of progression to end-stage kidney disease (ESKD) in DKD patients. Therefore, plasma NT-proBNP level could serve as a predictive marker for kidney prognosis in DKD patients.
Review
Urology & Nephrology
Limei Zhao, Xiaoyu Yang, Shengchao Zhang, Xiaoshuang Zhou
Summary: Through meta-analysis, we found that iron metabolism-related indicators are associated with the occurrence of acute kidney injury (AKI) after cardiac surgery. Specifically, the preoperative and 6-hour postoperative fractional excretion of urinary hepcidin, 24-hour postoperative urinary hepcidin, and urine hepcidin/urine creatinine ratio were significantly lower in patients who developed AKI. These parameters have the potential to be predictors for AKI after cardiac surgery in the future, but further large-scale and multicenter clinical research is needed to validate our conclusion.
Article
Urology & Nephrology
Noemi Del Toro-Cisneros, Nathan Berman-Parks, Adela Uribe-Perez, Adrian E. Caballero-Islas, Olynka Vega-Vega
Summary: The study evaluated the effectiveness of the renal angina index (RAI) in predicting severe acute kidney injury (AKI) in critically ill COVID-19 patients and proposed a modified RAI (mRAI) for this population. The results showed that mRAI performed better than RAI in predicting severe AKI and has important implications for risk stratification in critically ill COVID-19 patients.
Article
Urology & Nephrology
Qidong Ren, Yangzhong Zhou, Huiting Luo, Gang Chen, Yan Han, Ke Zheng, Yan Qin, Xuemei Li
Summary: This study investigated the association between carbohydrate intake and all-cause mortality in US adult CKD patients. The study found that CKD patients had a lower risk of mortality when consuming 30-45% energy from carbohydrates and 5-20% energy from sugar. Additionally, replacing carbohydrate intake with protein (up to 30%) and/or non-sugar carbohydrates (up to 55%) reduced the risk of all-cause mortality.
Article
Urology & Nephrology
Bidan Zheng, Dongfang Lu, Xiuping Chen, Yinghua Yin, Weiying Chen, Xiaowan Wang, Huanmei Lin, Peng Xu, Aihua Wu, Bo Liu
Summary: The study aimed to investigate the effect of tripterygium glycosides (TGs) on regulating abnormal lipid deposition in nephrotic syndrome (NS) rats. The results showed that TGs improved biomedical indexes, reduced kidney tissue pathological changes and lipid deposition, decreased renal oxidative damage and apoptosis. TGs may be a new strategy for reducing renal lipotoxicity in NS.
Article
Urology & Nephrology
Erdem Cankaya, Murat Altunok
Summary: This study aimed to investigate the relationship between serum albumin levels at different time points during peritoneal dialysis and mortality, risk of peritonitis, and decline in residual renal function. The results showed a significant correlation between first-year and mean albumin levels with mortality and risk of peritonitis, while baseline albumin levels did not show a significant correlation with these outcomes.
Review
Urology & Nephrology
Han Zhang, Juan Chen, Ying Zhang, Na Zhao, Dongmei Xu
Summary: This meta-analysis and systematic review found that belimumab plus standard therapy was more effective in improving renal function and reducing the risk of renal flare and progression to end-stage renal disease in patients with lupus nephritis. Moreover, it had a favorable safety profile.
Article
Urology & Nephrology
Yue Li, Gui-Chen Ling, Rui-Bin Ni, Shi-Hao Ni, Shu-Ning Sun, Xin Liu, Jian-Ping Deng, Xiao-Lu Ou-Yang, Jin Li, Shao-Xiang Xian, Ling-Jun Wang, Tao-Chun Ye, Lu Lu
Summary: This study analyzed data from two cohorts to investigate the association between dietary total antioxidant capacity (DTAC) and all-cause and CVD mortality risk in CKD patients. The results showed an L-shaped association between DTAC and all-cause mortality in CKD stages 1-2, with higher dietary total antioxidant intake associated with lower mortality risk. However, no similar benefits were observed for patients with CKD stages 3-5 or albuminuria.
