Transplantation

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Article Transplantation

Removing race from the CKD-EPI equation and its impact on prognosis in a predominantly White European population

Edouard L. Fu, Josef Coresh, Morgan E. Grams, Catherine M. Clase, Carl-Gustaf Elinder, Julie Paik, Chava Ramspek, Lesley A. Inker, Andrew S. Levey, Friedo W. Dekker, Juan J. Carrero

Summary: Implementing the 2021 CKD-EPI equation in predominantly White European populations would slightly increase eGFR and reclassify a significant proportion of CKD patients to a higher eGFR category. eGFR by both equations strongly predicted outcomes.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2023)

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Editorial Material Gastroenterology & Hepatology

Clinical Factors Associated With Lack of Serological Response to SARS-CoV-2 Messenger RNA Vaccine in Liver Transplantation Recipients

George Cholankeril, Alsadiq Al-Hillan, Brandon Tarlow, Daniela Abrams, Jake S. Jacobs, Norma P. Flores, Abbas Rana, Fasiha Kanwal, John A. Goss

LIVER TRANSPLANTATION (2022)

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Letter Surgery

Effect of nirmatrelvir/ritonavir on calcineurin inhibitor levels: Early experience in four SARS-CoV-2 infected kidney transplant recipients

Aileen X. Wang, Alan Koff, Diana Hao, Natascha M. Tuznik, Yihung Huang

AMERICAN JOURNAL OF TRANSPLANTATION (2022)

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Article Engineering, Biomedical

Outcomes after extracorporeal membrane oxygenation support in COVID-19 and non-COVID-19 patients

Chitaru Kurihara, Adwaiy Manerikar, Catherine Aiyuan Gao, Satoshi Watanabe, Viswajit Kandula, Alexandra Klonis, Vanessa Hoppner, Azad Karim, Mark Saine, David D. Odell, Kalvin Lung, Rafael Garza-Castillon, Samuel S. Kim, James McCauley Walter, Richard G. Wunderink, G. R. Scott Budinger, Ankit Bharat

Summary: Comparison of outcomes between COVID-19 and non-COVID-19 patients undergoing V-V ECMO support showed similar survival rates despite longer support duration for COVID-19 patients. Late initiation of ECMO in COVID-19 patients led to extremely high mortality rates, emphasizing the importance of early initiation for improved outcomes.

ARTIFICIAL ORGANS (2022)

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Review Transplantation

SGLT2 inhibition requires reconsideration of fundamental paradigms in chronic kidney disease, 'diabetic nephropathy', IgA nephropathy and podocytopathies with FSGS lesions

Hans-Joachim Anders, Anna Julie Peired, Paola Romagnani

Summary: The DAPA-CKD trial demonstrated that the SGLT2 inhibitor, dapagliflozin, attenuates the progression of chronic kidney disease (CKD) with proteinuria in patients with or without diabetes. This has significant implications for the understanding and treatment of CKD, suggesting that SGLT2 inhibition should be a central component in CKD management regardless of diabetes status. It may also impact the treatment approaches for IgA nephropathy and focal segmental glomerulosclerosis.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2022)

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Letter Surgery

Waning antibody response and cellular immunity 6 months after third dose SARS-Cov-2 mRNA BNT162b2 vaccine in kidney transplant recipients

Dominique Bertrand, Veronique Lemee, Charlotte Laurent, Mathilde Lemoine, Melanie Hanoy, Frank Le Roy, Dorian Nezam, Diana Pruteanu, Ludivine Lebourg, Steven Grange, Jean-Christophe Plantier, Olivier Boyer, Dominique Guerrot, Sophie Candon

AMERICAN JOURNAL OF TRANSPLANTATION (2022)

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Review Immunology

Impact of COVID-19 in hematopoietic stem cell transplant recipients: A systematic review and meta-analysis

Moazzam Shahzad, Sibgha Gull Chaudhary, Muhammad U. Zafar, Maha A. Hassan, Ali Hussain, Fatima Ali, Iqra Anwar, Mamoon Ahmed, Nausheen Ahmed, Sharad Khurana, Muhammad A. Rauf, Faiz Anwar, Peiman Hematti, Natalie S. Callander, Sunil H. Abhyankar, Joseph P. McGuirk, Muhammad Umair Mushtaq

Summary: This study analyzed data from 19 original studies and found that HSCT recipients have a high risk of mortality and clinical complications due to COVID-19, emphasizing the need for ongoing vigilance and aggressive management.

TRANSPLANT INFECTIOUS DISEASE (2022)

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Letter Biophysics

Safety and feasibility of outpatient chimeric antigen receptor (CAR) T-cell therapy: experience from a tertiary care center

Azra Borogovac, Amany Keruakous, Michelle Bycko, Jennifer Holter Chakrabarty, Sami Ibrahimi, Mohamad Khawandanah, George B. Selby, Carrie Yuen, Sarah Schmidt, Marcus T. Autry, Taha Al-Juhaishi, Matthew J. Wieduwilt, Adam S. Asch

BONE MARROW TRANSPLANTATION (2022)

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Article Transplantation

Management of obesity in kidney transplant candidates and recipients: A clinical practice guideline by the DESCARTES Working Group of ERA

Gabriel C. Oniscu, Daniel Abramowicz, Davide Bolignano, Ilaria Gandolfini, Rachel Hellemans, Umberto Maggiore, Ionut Nistor, Stephen O'Neill, Mehmet Sukru Sever, Muguet Koobasi, Evi Nagler

Summary: The clinical practice guideline Management of Obesity in Kidney Transplant Candidates and Recipients provides recommendations for addressing obesity in individuals with end-stage kidney disease, emphasizing shared decision-making and evidence-based treatment approaches following systematic reviews.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2022)

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Article Transplantation

Mineralocorticoid receptor antagonists for nephroprotection and cardioprotection in patients with diabetes mellitus and chronic kidney disease

Alberto Ortiz, Charles J. Ferro, Olga Balafa, Michel Burnier, Robert Ekart, Jean-Michel Halimi, Reinhold Kreutz, Patrick B. Mark, Alexandre Persu, Patrick Rossignol, Luis M. Ruilope, Roland E. Schmieder, Jose M. Valdivielso, Lucia Del Vecchio, Carmine Zoccali, Francesca Mallamaci, Pantelis Sarafidis

Summary: Diabetic kidney disease (DKD) is the most common cause of chronic kidney disease (CKD), with high risks of kidney failure and cardiovascular death for patients with CKD, especially those with diabetes. Renin-angiotensin system (RAS) blockers and sodium-glucose co-transporter-2 inhibitors (SGLT2is) have shown some protective effects, but the risks remain high. Steroidal mineralocorticoid receptor antagonists (MRAs) may provide potential benefits, but safety concerns exist. The FInerenone in reducing kiDnEy faiLure and dIsease prOgression in DKD (FIDELIO-DKD) study has shown promising results for non-steroidal MRA finerenone.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2023)

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Article Surgery

Immune Response to Third Dose BNT162b2 COVID-19 Vaccine Among Kidney Transplant Recipients-A Prospective Study

Dafna Yahav, Ruth Rahamimov, Tiki Mashraki, Naomi Ben-Dor, Tali Steinmetz, Timna Agur, Boris Zingerman, Michal Herman-Edelstein, Shelly Lichtenberg, Haim Ben-Zvi, Erez Bar-Haim, Hila Cohen, Shahar Rotem, Uri Elia, Ili Margalit, Benaya Rozen Zvi

Summary: The immune response to two doses of SARS-CoV-2 mRNA vaccine is limited among kidney transplant recipients. This study aimed to evaluate the humoral and cellular response to a third dose of the BNT162b2 vaccine. The results showed that the third dose improved the immune response among kidney transplant recipients, although 30% of them remained seronegative. Temporary reduction of immunosuppression before vaccination was found to improve the antibody response.

TRANSPLANT INTERNATIONAL (2022)

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Article Immunology

Perfusate Enzymes and Platelets Indicate Early Allograft Dysfunction After Transplantation of Normothermically Preserved Livers

Annemarie Weissenbacher, Christina Bogensperger, Rupert Oberhuber, Andras Meszaros, Silvia Gasteiger, Hanno UlmkavyaBer, Valeria Berchtold, Felix J. Krendl, Margot Fodor, Franka Messner, Theresa Hautz, Giorgi Otarashvili, Thomas Resch, Christian Margreiter, Manuel Maglione, Christian Irsara, Andrea Griesmacher, Marc Raynaud, Robert Breitkopf, Jakob Troppmair, Dietmar Ofner, Benno Cardini, Stefan Schneeberger

Summary: This study found that perfusate parameters during normothermic machine perfusion (NMP) can predict early allograft dysfunction (EAD) after liver transplantation. Aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, alkaline phosphatase, and sodium levels in the perfusate were correlated with EAD. Additionally, the number of perfusate platelets and von Willebrand Factor antigen were also important indicators for EAD occurrence. Lower perfusate pH was associated with a higher risk of EAD.

TRANSPLANTATION (2022)

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Article Hematology

Hematopoietic Cell Transplantation after CD19 Chimeric Antigen Receptor T Cell-Induced Acute Lymphoblastic Leukemia Remission Confers a Leukemia-Free Survival Advantage

Corinne Summers, Qian Vicky Wu, Colleen Annesley, Marie Bleakley, Ann Dahlberg, Prabha Narayanaswamy, Wenjun Huang, Jenna Voutsinas, Adam Brand, Wendy Leisenring, Michael C. Jensen, Julie R. Park, Rebecca A. Gardner

Summary: This study evaluated the effect of consolidative HCT on leukemia-free survival (LFS) in pediatric and young adult subjects following CD19 CART cell induced remission. The results showed that consolidative HCT improved LFS specifically in subjects who had no prior history of HCT and those with short functional CART cell persistence.

TRANSPLANTATION AND CELLULAR THERAPY (2022)

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Article Engineering, Biomedical

Observational study of thrombosis and bleeding in COVID-19 VV ECMO patients

Brianda Ripoll, Antonio Rubino, Martin Besser, Chinmay Patvardhan, William Thomas, Karen Sheares, Hilary Shanahan, Bobby Agrawal, Stephen Webb, Alain Vuylsteke

Summary: In patients with COVID-19 requiring veno-venous ECMO support, a high prevalence of VTE and a significant number of hemorrhages were observed. Extracorporeal oxygenation and whole body CT scans played a crucial role in diagnosing and managing thrombotic and bleeding events in these severely ill patients.

INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS (2022)

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Article Surgery

Augmenter of liver regeneration-mediated mitophagy protects against hepatic ischemia/reperfusion injury

Wei-ning Kong, Wen Li, Chun Bai, Yuan Dong, Yuan Wu, Wei An

Summary: Delivery of the ALR gene can alleviate hepatic I/R injury by activating the autophagy pathway via Mfn2, promoting Parkin translocation and mitochondrial mitophagy. Deletion of Mfn2 leads to mitochondrial dysfunction and increased cell apoptosis, while supplementation of Mfn2 prevents autophagy inhibition, reduces mitochondrial dysfunction, and decreases cell apoptosis.

AMERICAN JOURNAL OF TRANSPLANTATION (2022)

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Article Surgery

Outcome of liver transplantation with grafts from brain-dead donors treated with dual hypothermic oxygenated machine perfusion, with particular reference to elderly donors

Damiano Patrono, Davide Cussa, Veronica Sciannameo, Elena Montanari, Rebecca Panconesi, Paola Berchialla, Mirella Lepore, Alessandro Gambella, Giorgia Rizza, Giorgia Catalano, Stefano Mirabella, Francesco Tandoi, Francesco Lupo, Roberto Balagna, Mauro Salizzoni, Renato Romagnoli

Summary: Dual hypothermic oxygenated machine perfusion (D-HOPE) improves preservation and outcomes in liver transplantation, especially when utilizing donors after neurological determination of death (DBD). D-HOPE reduces early graft failure, complications, and improves survival for both patients and grafts, including elderly donors.

AMERICAN JOURNAL OF TRANSPLANTATION (2022)

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Article Surgery

COVID-19 therapeutics and outcomes among solid organ transplant recipients during the Omicron BA.1 era

Jessica Hedvat, Nicholas W. Lange, David M. Salerno, Ersilia M. DeFilippis, Danielle Kovac, Heather Corbo, Justin K. Chen, Jason Y. Choe, Jennifer H. Lee, Anastasia Anamisis, Douglas L. Jennings, Giovanna Codispodo, Tara Shertel, Robert S. Brown, Marcus R. Pereira

Summary: This study aimed to investigate the treatment outcomes of novel COVID-19 therapeutics in solid organ transplant recipients. The results showed that patients treated with nirmatrelvir/ritonavir or sotrovimab had a lower risk of hospitalization or death within 30 days compared to those who received no specific treatment.

AMERICAN JOURNAL OF TRANSPLANTATION (2022)

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Review Immunology

Renal Normothermic Machine Perfusion: The Road Toward Clinical Implementation of a Promising Pretransplant Organ Assessment Tool

Tim L. Hamelink, Baran Ogurlu, Julie De Beule, Veerle A. Lantinga, Merel B. F. Pool, Leonie H. Venema, Henri G. D. Leuvenink, Ina Jochmans, Cyril Moers

Summary: The increased utilization of high-risk renal grafts for transplantation requires optimization of pretransplant organ assessment strategies. Normothermic machine perfusion (NMP) creates near-physiological conditions, which might facilitate a more objective assessment of organ quality before transplantation. However, to date, no validated sets of on-pump viability markers exist nor are there unified NMP protocols. This review provides a critical overview of the fundamentals of current renal NMP protocols and proposes a framework to approach further development of ex vivo organ evaluation.

TRANSPLANTATION (2022)

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Article Surgery

Prolonged preservation by hypothermic machine perfusion facilitates logistics in liver transplantation: A European observational cohort study

Isabel M. A. Brueggenwirth, Matteo Mueller, Veerle A. Lantinga, Stefania Camagni, Riccardo De Carlis, Luciano De Carlis, Michele Colledan, Daniele Dondossola, Moritz Drefs, Janina Eden, Davide Ghinolfi, Dionysios Koliogiannis, Georg Lurje, Tommaso M. Manzia, Diethard Monbaliu, Paolo Muiesan, Damiano Patrono, Johann Pratschke, Renato Romagnoli, Michel Rayar, Federico Roma, Andrea Schlegel, Philipp Dutkowski, Robert J. Porte, Vincent E. de Meijer

Summary: Prolonged hypothermic oxygenated machine perfusion (HOPE) preservation of donor livers is safe and can lead to good outcomes in liver transplantation, with low incidence of complications and high survival rates. It can also reduce ischemia-reperfusion injury-related complications.

AMERICAN JOURNAL OF TRANSPLANTATION (2022)

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Article Immunology

Normothermic Ex Vivo Kidney Perfusion for Human Kidney Transplantation: First North American Results

Laura Mazilescu, Peter Urbanellis, S. Joseph Kim, Toru Goto, Yuki Noguchi, Ana Konvalinka, Trevor W. Reichman, Blayne A. Sayed, Istvan Mucsi, Jason Y. Lee, Lisa A. Robinson, Anand Ghanekar, Markus Selzner

Summary: This study demonstrates the safety and feasibility of normothermic ex vivo kidney perfusion (NEVKP) for deceased donor kidney transplantation. However, NEVKP did not show significant improvement in graft function and survival compared to traditional hypothermic machine perfusion. Further research is needed to explore the potential benefits of NEVKP in reducing cold ischemia, improving graft function, and assessing expanded criteria kidney grafts.

TRANSPLANTATION (2022)

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