Transplantation

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Article Surgery

Oscillometry in Stable Single and Double Lung Allograft Recipients Transplanted for Interstitial Lung Disease: Results of a Multi-Center Australian Study

Joan P. Y. Sim, Kristopher Nilsen, Brigitte M. Borg, Bronwyn Levvey, Jaideep Vazirani, Samantha Ennis, Marshall Plit, Gregory I. Snell, David R. Darley, Katrina O. Tonga

Summary: This study assessed respiratory mechanics in patients with interstitial lung disease after single lung transplantation and double lung transplantation. The results showed that lung function was significantly lower after single lung transplantation compared to double lung transplantation, while resistance was similar but reactance was significantly worse. The model results were consistent with the actual measurements. These findings suggest the important role of elastic properties in the pathophysiology, and oscillometry may provide further insight into physiological changes after transplantation.

TRANSPLANT INTERNATIONAL (2023)

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Article Engineering, Biomedical

Removal characteristics of presepsin by operating conditions and hemofilter

Tatsumi Yamasaki, Yasuto Miyamoto, Takayuki Goto, Yuuichi Oda, Takeshi Yano, Masahiko Taniguchi, Tetsuro Shirasaka

Summary: This study investigated the removal properties of presepsin by continuous hemodiafiltration and found that hemofiltration is more efficient in removing presepsin compared to hemodialysis. Additionally, the main removal mechanism was identified as adsorption when using a polymethylmethacrylate hemofilter. These findings have important clinical implications for the accuracy of presepsin measurement and the diagnosis of sepsis.

JOURNAL OF ARTIFICIAL ORGANS (2023)

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Article Biophysics

Comparison of fludarabine/melphalan (FluMel) with fludarabine/melphalan/BCNU or thiotepa (FBM/FTM) in patients with AML in first complete remission undergoing allogeneic hematopoietic stem cell transplantation - a registry study on behalf of the EBMT Acute Leukemia Working Party

Jesus Duque-Afonso, Juergen Finke, Maud Ngoya, Jacques-Emmanuel Galimard, Charles Craddock, Kavita Raj, Adrian Bloor, Emma Nicholson, Matthias Eder, Orchard Kim, Thomas Valerius, John A. Snowden, Eleni Tholouli, Charles Crawley, Matthew Collin, Keith M. O. Wilson, Alain Gadisseur, Rachel Protheroe, Eva Maria Wagner-Drouet, Bipin N. Savani, Alexandros Spyridonidis, Fabio Ciceri, Arnon Nagler, Mohamad Mohty

Summary: This study compared different conditioning protocols for AML patients with intermediate/poor risk cytogenetics. The results showed that adding a second alkylating agent to the conditioning regimen improved overall survival and reduced non-relapse mortality, with no significant difference in relapse incidence.

BONE MARROW TRANSPLANTATION (2023)

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Review Immunology

Infections in children following chimeric antigen receptor T-cell therapy for B-cell acute lymphoblastic leukemia

Yonatan Diamond, Maddie Gilsenan, Stacie Shiqi Wang, Diane Hanna, Rachel Conyers, Theresa Cole, David Hughes, Jacqueline Fleming, Deborah Meyran, Claudia Toro, Vajiranee Malalasekera, Seong Lin Khaw, Gabrielle M. Haeusler

Summary: This study provides important information on the spectrum of infections encountered in pediatric patients with B-ALL post CAR-T therapy. The burden of infectious complications post CAR-T therapy in our cohort is lower than previously reported in the literature, suggesting that our prophylaxis recommendations are effective in this population.

TRANSPLANT INFECTIOUS DISEASE (2023)

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Article Surgery

Incidence, risk factors, and outcomes of postoperative stroke in combined heart-lung transplantation: A retrospective cohort study of the UNOS registry

Armaan F. Akbar, Benjamin L. Shou, Alfred J. Casillan, Ahmet Kilic, Errol L. Bush, Glenn Whitman, Sung-Min Cho

Summary: Stroke after combined heart-lung transplantation is a well-characterized complication. This study found that the incidence of postoperative stroke is increasing, with extracorporeal membrane oxygenation and pre-transplant implantable defibrillator being independent risk factors.

CLINICAL TRANSPLANTATION (2023)

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Article Surgery

A comparison between patients with various etiologies of cirrhosis and examination of cardiac risk factors limiting survival to liver transplantation

Michael J. Delicce, Joseph Mauch, Omar T. Sims, Ruishen Lyu, Heather Kren, Rose Bartow, Donna Ferchill, Abel Joseph, Maan Fares, Jamile Wakim-Fleming

Summary: This retrospective cohort study aimed to assess differences in patient survival on the waitlist for liver transplantation based on etiologies of cirrhosis, and to identify cardiac risk factors that predict survival failure during the waitlist period. The study found that severe coronary artery disease and tricuspid regurgitation at the time of listing were associated with increased risk for survival failure, regardless of the etiology of liver disease. The study suggests that diagnostic assessment of coronary and valvular disease should be considered for all patients undergoing evaluation for liver transplantation.

CLINICAL TRANSPLANTATION (2023)

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Article Pediatrics

A fluid relationship: Calcineurin inhibitors and pericardial effusions

Mark Lee Westbroek, Mahvish Qureshi Rahim, Michael Marshall Ross, April Leigh Rahrig

Summary: This study retrospectively evaluated the management of pericardial effusion (PEF) in pediatric patients post-HSCT. The results showed that continuing calcineurin inhibitor (CNI) therapy for graft-versus-host disease (GVHD) prophylaxis did not have a negative impact on the disease course of PEF.

PEDIATRIC TRANSPLANTATION (2023)

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Article Surgery

Day 100 Natural Killer Cell/CD14+HLA-DRDIM ratio and survival in lymphoma post-autologous peripheral blood hematopoietic stem cell transplantation

Luis F. Porrata, Stephen M. Ansell, Ivana N. Micallef, Patrick B. Johnston, Jose C. Villasboas, Jonas Paludo, Urshila Durani, Svetomir N. Markovic

Summary: This study evaluated the prognostic capability of the Day 100 NKC/CD14(+)HLA-DRDIM ratio in lymphoma patients who underwent autologous peripheral blood hematopoietic stem cell transplantation (APBHSCT). The results showed that a Day 100 NKC/CD14(+)HLA-DRDIM ratio >= 1.67 was associated with better overall survival and progression-free survival.

CLINICAL TRANSPLANTATION (2023)

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Article Surgery

Association of body mass index with post-liver transplant outcomes

Jessica M. Ruck, Amy M. Shui, Alexis A. Jefferis, Andres Duarte Rojo, Robert S. Rahimi, Daniel R. Ganger, Elizabeth C. Verna, Matthew Kappus, Daniela P. Ladner, Dorry L. Segev, Michael Volk, Amit Tevar, Elizabeth A. King, Jennifer C. Lai

Summary: Obese liver transplant recipients have similar post-transplant survival compared to non-obese recipients, but longer hospital stays and higher likelihood of wound dehiscence and venous thrombosis. Monitoring for obesity-related complications such as wound dehiscence and venous thrombosis is important for obese recipients.

CLINICAL TRANSPLANTATION (2023)

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Letter Immunology

A case of skin and soft tissue infection in a lung transplant recipient

Flavia Moran Viacava, Maria Veronica Bandres, Aaron Mishkin

TRANSPLANT INFECTIOUS DISEASE (2023)

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Review Transplantation

Cell-cell communication in kidney fibrosis

Meizhi He, Zhao Liu, Li Li, Youhua Liu

Summary: Kidney fibrosis is a common outcome of chronic kidney diseases, and cell-cell communication plays a vital role in coordinating complex actions during renal fibrogenesis. Traditional cell-cell communication is mediated by direct contact or soluble factors, but recent evidence suggests that extracellular vesicles can also transfer biomolecules between cells.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2023)

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Article Surgery

Detrimental impact of early biopsy-proven rejection in liver transplantation

David D. Aufhauser Jr, Lily Stalter, Nicholas Marka, Glen Leverson, David P. Al-Adra, David P. Foley

Summary: There is conflicting evidence on whether early acute cellular rejection affects long-term outcomes in liver transplantation. A retrospective study found that early biopsy-proven acute cellular rejection (EBPR) is associated with decreased graft survival, increased risk of late rejection, and susceptibility to infection.

CLINICAL TRANSPLANTATION (2023)

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Article Surgery

Impact of pancreas transplantation alone on kidney function: A multicenter clinical cohort study

Ravinder Jeet Kaur, Syed Saad Mujtahedi, Jonathan A. Fridell, Xiomara Benavides, Byron Smith, Timothy S. Larson, Shafaq R. Rizvi, Aleksandra Kukla, Patrick Dean, Yogish C. Kudva, Jon Odorico, Mark Stegall

Summary: This multicenter study retrospectively assessed the impact of pancreas transplantation on kidney function in patients with type 1 diabetes. The results showed that kidney function initially declined after transplantation but stabilized with slow progression. Female patients and those with better kidney function were more likely to experience declining kidney function within 5 years post-transplantation.

CLINICAL TRANSPLANTATION (2023)

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Article Surgery

Administrative coding of frailty: Its association with clinical outcomes and resource use in kidney transplantation

Saad Mallick, Sara Sakowitz, Syed Shahyan Bakhtiyar, Nikhil Chervu, Alberto Valenzuela, Shineui Kim, Peyman Benharash

Summary: Frail patients undergoing kidney transplantation were found to have significantly higher odds of in-hospital mortality, longer hospital stays, increased hospitalization costs, greater risk of major perioperative complications, and higher likelihood of non-home discharge compared to their non-frail counterparts. These findings highlight the importance of identifying and addressing frailty in this patient population to improve surgical outcomes post-transplantation.

CLINICAL TRANSPLANTATION (2023)

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Article Surgery

Pancreatic steatosis is an independent risk factor for post-transplant diabetes mellitus in kidney transplant patients

Nuri Baris Hasbal, Sidar Copur, Ibrahim B. Peltek, Ali Mutlu, Hande Ozen Atalay, Yavuz E. Kesgin, Afak Durur Karakaya, Dimitrie Siriopol, Burak Kocak, Mehmet Kanbay

Summary: This study found that pancreatic steatosis is an independent predictive factor for post-transplant diabetes mellitus in kidney transplant patients.

CLINICAL TRANSPLANTATION (2023)

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Article Surgery

Simultaneous split liver/kidney transplantation: A national and single center experience report

Radhika Rastogi, Paola A. Vargas, Jose Oberholzer, Shawn Pelletier, Nicolas Goldaracena

Summary: Simultaneous split liver and kidney transplantation (SSLK) is a safe and feasible option for patients with both end-stage liver disease and end-stage renal disease, with high survival rates.

CLINICAL TRANSPLANTATION (2023)

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Article Surgery

Re-assessing prolonged cold ischemia time in kidney transplantation through machine learning consensus clustering

Caroline C. Jadlowiec, Charat Thongprayoon, Supawit Tangpanithandee, Rachana Punukollu, Napat Leeaphorn, Matthew Cooper, Wisit Cheungpasitporn

Summary: Unsupervised machine learning identified two clinically distinct clusters among deceased donor kidney transplant recipients with prolonged CIT, highlighting differences in patient and donor characteristics and outcomes. Despite differences, both clusters showed good survival rates, providing opportunities for transplant centers to explore ways to increase CIT.

CLINICAL TRANSPLANTATION (2023)

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Article Surgery

Severe hepatic encephalopathy with mechanical ventilation may inform waitlist priority in acute liver failure: A UNOS database analysis

Jiayi Ma, James E. Slaven, Lauren Nephew, Kavish R. Patidar, Archita P. Desai, Eric Orman, Chandrashekhar Kubal, Naga Chalasani, Marwan Ghabril

Summary: The study found that cumulative organ failure, especially neurologic and respiratory failure, significantly impacts waitlist and post-LT mortality in patients with ALF, which may inform risk-prioritized allocation of organs.

CLINICAL TRANSPLANTATION (2023)

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Article Cardiac & Cardiovascular Systems

Lung transplantation outcomes in patients from socioeconomically distressed communities

Jad Malas, Qiudong Chen, Dominick Megna, Lorenzo Zaffiri, Reinaldo E. Rampolla, Natalia Egorova, Dominic Emerson, Pedro Catarino, Joanna Chikwe, Michael E. Bowdish

Summary: The study found that lung transplant recipients from economically distressed communities have lower post-transplant survival rates, which may be related to younger recipient age, different racial composition, lower education levels, and insurance situations. Therefore, efforts should be made to increase resource allocation and further research to understand factors that mitigate this inequality.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2023)

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Editorial Material Cardiac & Cardiovascular Systems

ISHLT Transplant Registry relaunch: A call to action Notes from the ISHLT Transplant Registry Director

Rebecca Cogswell

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2023)

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