Toxicology

Review Environmental Sciences

A critical review on the treatment of dye-containing wastewater: Ecotoxicological and health concerns of textile dyes and possible remediation approaches for environmental safety

Rania Al-Tohamy, Sameh S. Ali, Fanghua Li, Kamal M. Okasha, Yehia A. -G. Mahmoud, Tamer Elsamahy, Haixin Jiao, Yinyi Fu, Jianzhong Sun

Summary: The synthetic dyes used in the textile industry cause pollution in water bodies, which has negative consequences on the environment and human health. It is important to effectively treat dye-containing wastewater using eco-friendly technologies to reduce contamination of aquatic habitats and natural water resources. This review discusses the effects of textile dyes on water bodies, aquatic flora, and human health, and compares various technologies for removing dyes from textile wastewater.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2022)

Article Food Science & Technology

Recent advances in carbon nanomaterials-based electrochemical sensors for food azo dyes detection

Hassan Karimi-Maleh, Hadi Beitollahi, P. Senthil Kumar, Somayeh Tajik, Peyman Mohammadzadeh Jahani, Fatemeh Karimi, Ceren Karaman, Yasser Vasseghian, Mehdi Baghayeri, Jalal Rouhi, Pau Loke Show, Saravanan Rajendran, Li Fu, Najmeh Zare

Summary: Azo dyes are widely used food colorants for their stability and affordability. However, they can have harmful impacts on living organs, necessitating the control of their content in food. Electro-analytical techniques have been favored for detecting azo dyes due to their sensitivity, selectivity, reproducibility, miniaturization, green nature, low cost, short sample preparation and detection time, and electrode modification capabilities. Carbon-based nanomaterials, such as carbon nanotubes (CNT) and graphene (Gr), have shown satisfactory results in the fabrication of electrochemical sensing systems for detecting the levels of azo dyes in various specimens.

FOOD AND CHEMICAL TOXICOLOGY (2022)

Article Pharmacology & Pharmacy

Prevention and Treatment of Monkeypox

John G. Rizk, Giuseppe Lippi, Brandon M. Henry, Donald N. Forthal, Youssef Rizk

Summary: Human monkeypox is a zoonotic disease similar to smallpox. It can be transmitted through contact with infected animals, direct contact, respiratory droplets, and contaminated objects. Various medical countermeasures, including vaccines and antiviral drugs, are available for the treatment of monkeypox.

DRUGS (2022)

Article Food Science & Technology

Determination of D&C Red 33 and Patent Blue V Azo dyes using an impressive electrochemical sensor based on carbon paste electrode modified with ZIF-8/g-C3N4/Co and ionic liquid in mouthwash and toothpaste as real samples

Hassan Karimi-Maleh, Rozhin Darabi, Mehdi Shabani-Nooshabadi, Mehdi Baghayeri, Fatemeh Karimi, Jalal Rouhi, Marzieh Alizadeh, Onur Karaman, Yasser Vasseghian, Ceren Karaman

Summary: Synthetic azo dyes are widely used in various industries, posing a risk to human health. This study developed a new carbon paste electrode modified with ZIF-8/g-C3N4/Co nanocomposite and 1-methyl-3-butylimidazole bromide as an ionic liquid for the sensitive detection of common dyes in cosmetics.

FOOD AND CHEMICAL TOXICOLOGY (2022)

Article Pharmacology & Pharmacy

Nirmatrelvir Plus Ritonavir: First Approval

Yvette N. Lamb

Summary: Nirmatrelvir plus ritonavir is a medication developed for the treatment and post-exposure prophylaxis of COVID-19. It received authorization in the UK and EU for use in adults at high risk for severe COVID-19. Nirmatrelvir is an inhibitor of SARS-CoV-2 main protease, while ritonavir is a protease inhibitor and CYP3A inhibitor.

DRUGS (2022)

Article Food Science & Technology

Electrochemical quantification of mancozeb through tungsten oxide/ reduced graphene oxide nanocomposite: A potential method for environmental remediation

Jamil A. Buledi, Nasrullah Mahar, Arfana Mallah, Amber R. Solangi, Ismail M. Palabiyik, Nadeem Qambrani, Fatemeh Karimi, Yasser Vasseghian, Hassan Karimi-Maleh

Summary: This study presents a method for electrochemical monitoring of mancozeb using WO3/rGO nanocomposite. The nanocomposite was characterized and found to have good crystallinity and nanometric size. By modifying a glassy carbon electrode, the detection of mancozeb was achieved, and acceptable recovery values were obtained in real vegetable samples.

FOOD AND CHEMICAL TOXICOLOGY (2022)

Article Food Science & Technology

Recent advances in Ponceau dyes monitoring as food colorant substances by electrochemical sensors and developed procedures for their removal from real samples

Masoumeh Ghalkhani, Najmeh Zare, Fatemeh Karimi, Ceren Karaman, Marzieh Alizadeh, Yasser Vasseghian

Summary: This study comprehensively reviews the properties, applications, chemistry, and toxicity of Ponceau dyes as food colorants. It discusses the electrochemical analysis of Ponceau dyes and the various methods used to remove these dyes.

FOOD AND CHEMICAL TOXICOLOGY (2022)

Review Environmental Sciences

Exposure to per- and Polyfluoroalkyl Substances and Markers of Liver Injury: A Systematic Review and Meta-Analysis

Elizabeth Costello, Sarah Rock, Nikos Stratakis, Sandrah P. Eckel, Douglas Walker, Damaskini Valvi, Dora Cserbik, Todd Jenkins, Stavra A. Xanthakos, Rohit Kohli, Stephanie Sisley, Vasilis Vasiliou, Michele A. La Merrill, Hugo Rosen, David Conti, Rob McConnell, Leda Chatzi

Summary: This study conducted a systematic review and meta-analysis to evaluate the evidence of liver injury related to PFAS exposure. The results showed that PFAS exposure in rodents consistently resulted in higher ALT levels and steatosis, while in human studies, PFAS exposure was associated with elevated ALT levels.

ENVIRONMENTAL HEALTH PERSPECTIVES (2022)

Review Environmental Sciences

COF-Based Composites: Extraordinary Removal Performance for Heavy Metals and Radionuclides from Aqueous Solutions

He Gu, Xiaolu Liu, Suhua Wang, Zhongshan Chen, Hui Yang, Baowei Hu, Chi Shen, Xiangke Wang

Summary: This review highlights the categories, recent advances, and applications of covalent-organic-framework-based composites (COF-based composites). It specifically focuses on their efficient removal of heavy metals and radionuclides and compares their performance with other materials. Technologies for investigating the internal mechanism of pollutant removal by COF-based composites are also discussed and summarized, providing direction for further research. The opportunities and challenges of COF-based composites in heavy metal and radionuclide treatment are summarized, and potential research directions and applications are proposed.

REVIEWS OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY (2022)

Review Biochemistry & Molecular Biology

Imbalanced GSH/ROS and sequential cell death

Ting Liu, Li Sun, Yubin Zhang, Yonglin Wang, Jiang Zheng

Summary: This article reviews the impact of imbalance between ROS and GSH on cells, indicating that imbalance may lead to cell death. In addition, different factors leading to the disruption of cellular ROS and GSH balance are introduced.

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2022)

Article Environmental Sciences

The size and culturability of patient-generated SARS-CoV-2 aerosol

Joshua L. Santarpia, Vicki L. Herrera, Danielle N. Rivera, Shanna Ratnesar-Shumate, St. Patrick Reid, Daniel N. Ackerman, Paul W. Denton, Jacob W. S. Martens, Ying Fang, Nicholas Conoan, Michael V. Callahan, James V. Lawler, David M. Brett-Major, John J. Lowe

Summary: The study found evidence of viral replication in submicron aerosol samples from COVID-19 patients, further confirming the potential for airborne transmission of COVID-19. Therefore, it emphasizes the importance of using efficient respiratory protection in healthcare and public settings to limit transmission.

JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY (2022)

Review Environmental Sciences

Are We Underestimating Anthropogenic Microfiber Pollution? A Critical Review of Occurrence, Methods, and Reporting

Samantha N. Athey, Lisa M. Erdle

Summary: Anthropogenic microfibers are a widespread environmental contaminant that can be synthetic, semisynthetic, or natural. While most research has focused on synthetic fibers, natural and semisynthetic fibers also require further investigation.

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY (2022)

Article Food Science & Technology

Curcumin mitigates aflatoxin B1-induced liver injury via regulating the NLRP3 inflammasome and Nrf2 signaling pathway

Yingjie Wang, Fangju Liu, Mengru Liu, Xin Zhou, Min Wang, Kexin Cao, Sanjun Jin, Anshan Shan, Xingjun Feng

Summary: This study investigated the protective effects of curcumin against AFB1-induced liver injury in mice. Curcumin was found to attenuate AFB1-induced weight loss and liver damage by mitigating alterations in pathology and liver function. It reduced the accumulation of AFB1-DNA adducts in the liver and alleviated hepatotoxicity by inhibiting oxidative stress and potentiating detoxification enzymes. Additionally, curcumin reduced AFB1-induced pyroptosis and modulated the NLRP3 inflammasome and Nrf2 signaling pathways.

FOOD AND CHEMICAL TOXICOLOGY (2022)

Article Environmental Sciences

The role of solar energy and eco-innovation in reducing environmental degradation in China: Evidence from QARDL approach

FengSheng Chien, Ching-Chi Hsu, Zubaria Andlib, Muhammad I. Shah, Tahseen Ajaz, Mesfin G. Genie

Summary: In China, solar energy and eco-innovation have been identified as the two most effective channels for controlling CO2 emissions. Population size is causing a significant surge in CO2 emissions, while per capita income is positively associated with CO2 emissions.

INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT (2022)

Article Environmental Sciences

The Tire Wear Compounds 6PPD-Quinone and 1,3-Diphenylguanidine in an Urban Watershed

Cassandra Johannessen, Paul Helm, Brent Lashuk, Viviane Yargeau, Chris D. Metcalfe

Summary: The study found that toxic tire-wear compounds such as 6PPD-quinone and DPG were transported into the Don River in the Greater Toronto Area during heavy rain events.

ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY (2022)

Article Food Science & Technology

Amplified electrochemical sensor employing screen-printed electrode modified with Ni-ZIF-67 nanocomposite for high sensitive analysis of Sudan I in present bisphenol A

Hadi Beitollahi, Mahboobeh Shahsavari, Iran Sheikhshoaie, Somayeh Tajik, Peyman Mohammadzadeh Jahani, Sayed Zia Mohammadi, Abbas Aghaei Afshar

Summary: This study synthesized Ni-ZIF-67 nanocomposite using a facile method and demonstrated its application as a durable sensor for detecting Sudan I and bisphenol A. The results showed that the electrochemical response of the sensor was significantly increased compared to a bare electrode and had a low detection limit.

FOOD AND CHEMICAL TOXICOLOGY (2022)

Article Cell Biology

Protecting mitochondria via inhibiting VDAC1 oligomerization alleviates ferroptosis in acetaminophen-induced acute liver injury

Baolin Niu, Xiaohong Lei, Qingling Xu, Yi Ju, Dongke Xu, Liya Mao, Jing Li, Yufan Zheng, Ning Sun, Xin Zhang, Yimin Mao, Xiaobo Li

Summary: APAP overdose can lead to ferroptosis, and protecting mitochondria can alleviate APAP-induced hepatocyte ferroptosis by restoring ceramide and cardiolipin content. Specifically, inhibiting VDAC1 oligomerization can protect hepatocytes from AILI damage by restoring ceramide and cardiolipin levels.

CELL BIOLOGY AND TOXICOLOGY (2022)

Article Cell Biology

Exosomes derived from hepatitis B virus-infected hepatocytes promote liver fibrosis via miR-222/TFRC axis

Qidi Zhang, Ying Qu, Qingqing Zhang, Fei Li, Binghang Li, Zhenghong Li, Yuwei Dong, Lungen Lu, Xiaobo Cai

Summary: Exosomal miR-222 promotes liver fibrosis by inhibiting TFRC and TFRC-induced ferroptosis in HBV-infected hepatocytes. This study reveals the significance of miR-222 and TFRC in the process of liver fibrosis.

CELL BIOLOGY AND TOXICOLOGY (2023)

Review Pharmacology & Pharmacy

A narrative review of molecular mechanism and therapeutic effect of cannabidiol (CBD)

Jiangling Peng, Mingjie Fan, Chelsea An, Feng Ni, Wendong Huang, Jiankang Luo

Summary: CBD, an abundant non-psychoactive phytocannabinoid in cannabis extracts, has multiple therapeutic effects and potential applications in human diseases such as neuroprotection, antiepileptic, and anxiolytic properties. This narrative review summarizes the applications of CBD in human diseases from mechanism of action to clinical trials.

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2022)

Review Chemistry, Multidisciplinary

Biomedical applications and toxicities of carbon nanotubes

Shiv Kumar Prajapati, Akanksha Malaiya, Payal Kesharwani, Deeksha Soni, Aakanchha Jain

Summary: Carbon nanotubes have attractive properties and various potential applications, including drug delivery and diagnosis. Although their toxicities need to be considered, many studies have explored their biodegradation mechanism.

DRUG AND CHEMICAL TOXICOLOGY (2022)