Toxicology

Article Biochemistry & Molecular Biology

Anthropogenic increase of heavy metals in soil from a heavily contaminated area of China

Jiaxin Wang, Qingye Hou, Zhongfang Yang, Tao Yu, Riyang Wen

Summary: Evaluating the variation in heavy metal concentrations caused by human activities in contaminated areas is important. Different indices and reference elements are used to assess heavy metal pollution in soil, but they cannot evaluate the pollution caused by human activities. This study compared the concentrations of heavy metals in soil profiles in a contaminated area and a background area in China, finding higher concentrations in the contaminated area. The study also used prediction models to depict the increase in heavy metal concentrations in the topsoil due to anthropogenic activities.

ENVIRONMENTAL POLLUTANTS AND BIOAVAILABILITY (2023)

Review Biochemistry & Molecular Biology

An overview on the modulation of pesticide detoxification mechanism via salicylic acid in the plants

Arun Kumar, Pradeep Kumar Yadav, Shikha Singh, Anita Singh

Summary: The continuous use of pesticides has harmful effects on the ecosystem and accumulates in the food chain. Salicylic acid plays a role in regulating the toxicity of pesticides, but its significance is often overlooked. In the presence of salicylic acid, genes and proteins related to detoxification processes are upregulated, leading to a defense network against pesticide stress. This review aims to understand how salicylic acid is involved in pesticide detoxification to regulate stress in plants and explore its wider applications.

ENVIRONMENTAL POLLUTANTS AND BIOAVAILABILITY (2023)

Article Biochemistry & Molecular Biology

Elemental composition of PM10 in indoor environments of a scientific research institution and risk assessment

Salvador Reynoso-Cruces, Javier Miranda-Martin-Del-Campo, Juan Carlos Pineda-Santamaria

Summary: Synchronized indoor and outdoor sampling campaigns were conducted in Mexico City during the dry cold season to measure PM10 mass and elemental concentrations, identify particle origins and their penetration into indoor environments, and assess health risks. X-ray Fluorescence was used to measure concentrations of 18 elements, and Scanning Electron Microscopy was used to analyze selected samples. Outdoor mass concentrations were higher, while elemental concentrations were similar indoors and outdoors. Enrichment factors revealed the presence of geogenic elements, and Cluster Analysis identified common sources of elements and the penetration of outdoor particles indoors. Indoor emissions were distinguishable. Health risks associated with exposure to Mn, Fe, Ni, Cu, Zn, and Pb particles were low, with only Cr posing an ingestion risk. Hazard Quotients for outdoor Mn and Ni were higher than indoors.

ENVIRONMENTAL POLLUTANTS AND BIOAVAILABILITY (2023)

Article Biochemistry & Molecular Biology

In vitro toxicity assessment of atmospheric particulate matter on human lung and hepatic cells with agar membrane-based sampling and exposure strategy

Si-Si Chen, Zhi-Jie Tang, Zhao-Ming Cao, Hong-Juan Chen, Yi Lian, Xin Hu, Hong-Zhen Lian, Wei-Juan Zheng

Summary: Researchers proposed an efficient PM sampling and extraction method using agar membrane and validated its reliability and reproducibility with lung and hepatic cells. The PM extracted from agar membranes showed higher toxicity to HepG2 and HL7702 cells compared to that from PTFE filters. This work highlights the importance of assessing PM cytotoxicity from the perspective of extraction methods and cell lines.

ENVIRONMENTAL POLLUTANTS AND BIOAVAILABILITY (2023)

Article Chemistry, Applied

Crayfish shells-derived carbon dots as a fluorescence sensor for the selective detection of 4-nitrophenol

Jiannan Chen, Xiuhua Xia, Peizhen Li, Hang Yu, Yunfei Xie, Yahui Guo, Weirong Yao, He Qian, Yuliang Cheng

Summary: In this study, crayfish shells were used as precursors to prepare a new type of carbon dots through the hydrothermal method. The synthesized carbon dots showed strong blue fluorescence emission and were sensitive to quenching effect by 4-nitrophenol. Based on this, a facile and rapid fluorescence sensor was developed to detect 4-nitrophenol with a detection limit of 0.16 μM. The sensor was successfully applied for the detection of 4-nitrophenol in fresh crayfish meat and aquatic water samples.

FOOD AND AGRICULTURAL IMMUNOLOGY (2023)

Article Chemistry, Applied

Rapid diagnosis of Tobacco mosaic virus in tobacco using time-resolved fluorescence immunoassay

Yuan Ji, Yushuang Guo, Huimin Deng, Jianfeng Zhang, Yuemao Wang, En Dai, Ziyan Fan, Gangling Tang, Mengao Jia, Bo Ding

Summary: Tobacco mosaic virus (TMV) was detected in tobacco using a time-resolved fluorescence immunoassay (TRFIA) with a detection limit of 0.24 ng/mL. Monoclonal antibodies developed from TMV virions were conjugated to Eu3+ nanospheres. The specificity of the TRFIA platform was confirmed using ten species of tobacco-infecting phytopathogens. The TRFIA platform was successfully applied for on-site TMV testing in 10,000 tobacco leaf samples collected from five fields in Kunming, China.

FOOD AND AGRICULTURAL IMMUNOLOGY (2023)

Article Chemistry, Applied

Deep-sea-derived viridicatol relieves allergic response by suppressing MAPK and JAK-STAT signalling pathways of RBL-2H3 cells

Yan Liu, Zhendan Shu, Yan Li, Huiying Chen, Hong Liu, Xianwen Yang, Guangming Liu, Qingmei Liu

Summary: Our previous studies showed that viridicatol from the deep-sea-derived fungus Penicillium griseofulvum can regulate mast cell stabilization and relieve food allergy. To understand the molecular mechanisms, transcriptomes of viridicatol-treated RBL-2H3 cells were analyzed. Differentially expressed genes and enrichment analysis indicated that viridicatol played a significant role in mast cell stabilization by affecting MAPK and JAK-STAT signaling pathways.

FOOD AND AGRICULTURAL IMMUNOLOGY (2023)

Article Chemistry, Applied

Litopenaeus vannamei fermentation using selected Lactobacillus spp. to reduce its allergenicity

Hongyan Li, Zhihe Hu, Yali Yan

Summary: Fermentation with Lactobacillus can reduce the allergenicity of shrimp, providing a solution to the dietary challenges faced by shrimp allergy sufferers and reducing the risk of adverse reactions.

FOOD AND AGRICULTURAL IMMUNOLOGY (2023)

Article Toxicology

Endoplasmic reticulum stress mediates environmental particle-induced inflammatory response in bronchial epithelium

Li Pu, Fen Yi, Wen-jing Yu, Ya-jing Li, You-hui Tu, Ai-hui Xu, Yong Wang

Summary: This study examined the effects of particulate matter (PM) on endoplasmic reticulum (ER) stress in human bronchial epithelial (HBE) cells and identified potential molecular mechanisms. The results showed that PM exposure induced elevations in the ER stress hallmarks GRP78 and IRE1α in the HBE cells. Inhibition of ER stress alleviated the PM-induced effects and possibly regulated PM-induced inflammation through autophagy and NF-κB signaling pathways.

JOURNAL OF IMMUNOTOXICOLOGY (2023)

Article Biochemistry & Molecular Biology

Recyclable magnetic nanocomposites for efficient removal of cadmium ions from water: performance, mechanism and isotherm studies

Saad Melhi

Summary: In this study, an effective adsorbent, succinic acid functionalized Fe3O4@AMPA nanocomposite, was synthesized and used for the efficient removal of Cd(II) ions from aqueous media. Characterization of the Fe3O4@AMPA@SA nanocomposite was done using zeta potential, BET, TEM, TGA, and FTIR spectra. The batch experiment method was used to investigate the influence of pH value, initial Cd(II) concentration, adsorbent dosage, temperature, and contact time on the adsorption process. The results showed that the Fe3O4@AMPA@SA nanocomposite exhibited a maximum monolayer adsorption capacity of 265 mg g(-1) for Cd(II) ions.

ENVIRONMENTAL POLLUTANTS AND BIOAVAILABILITY (2023)

Article Biochemistry & Molecular Biology

Remediation of chromium-contaminated soil in semi-arid areas by combined chemical reduction and stabilization

Yiqing Pei, Yiming Yang, Lihua Chen, Yipeng Yang, Lingyan Song

Summary: The indoor simulation remediation experiment investigated the effects of different remediation agents, dosage, water-soil ratio, and remediation time on the reduction and stabilization efficiency of chromium-contaminated soil in semi-arid areas. The results showed that FeSO4 was the most effective reduction agent, and the optimal remediation conditions included a specific combination of dosage, biochar, water-soil ratio, and remediation time. After treatment, the leaching concentrations and content of Cr(VI) in the soil were significantly reduced and met the relevant standards.

ENVIRONMENTAL POLLUTANTS AND BIOAVAILABILITY (2023)

Review Biochemistry & Molecular Biology

Effect of cadmium exposure during and after pregnancy of female

Waseem Ali, Yusheng Bian, Hao Zhang, Izhar Hyder Qazi, Hui Zou, Jiaqiao Zhu, Zongping Liu

Summary: Cadmium is a widely used environmental pollutant that can cause various health issues, particularly related to reproductive health. This review focuses on the impact of cadmium exposure on female reproductive health, including during and after pregnancy. Cadmium exposure has been found to disrupt steroidogenesis, delay puberty, affect reproductive hormones, disturb menstrual cycles, increase the risk of premature births, and reduce birth weights in females. Additionally, prenatal exposure to cadmium has been shown to have differential effects on offspring, with more negative impacts on female offspring. Furthermore, lactation with cadmium-contaminated milk can lead to disparities in brain physiology, reflex changes, and physical immaturity in nursing babies. These findings highlight the importance of conducting further studies on the consequences of cadmium exposure on reproductive health.

ENVIRONMENTAL POLLUTANTS AND BIOAVAILABILITY (2023)

Article Biochemistry & Molecular Biology

Occurrence and risk assessment of perfluoroalkyl substances in the river basin around fluorine industry parks, China

Hongye Yao, Di Zhao, Weixia Wang, Zhuqiang Liu, Haiyun Zhou

Summary: Target analysis combined with traceability analysis was used to identify the type of PFASs present in surface water and sediment around fluorine industry parks (FIPs) in China. Risk characterisation ratio was employed to evaluate the risk posed by these PFASs to the surrounding river. The study found the presence of 10 and 15 PFASs in surface water and sediment, with concentrations reaching up to 32,674.0 ng/L and 17.84 ng/g, respectively. Short-chain PFASs, particularly perfluoropentanoic acid, were predominant. Source analysis suggested that PFASs in surface water originated from precursor degradation and atmospheric deposition, while the fluorine rubber industry was the main source for PFASs in sediment, especially short-chain compounds. A risk characterisation ratio analysis identified several compounds, including perfluorododecanoic acid, perfluorobutane sulfonate, perfluoroheptanoic acid, perfluoropentanoic acid, and perfluorohexanoic acid, as having relatively high risks.

ENVIRONMENTAL POLLUTANTS AND BIOAVAILABILITY (2023)

Article Biochemistry & Molecular Biology

Attenuating Effect of Spirulina (Arthrospira platensis) against Di (2-ethylhexyl) Phthalate Induced Toxicity in Wistar Rat

Munira Abdullah Rashed Alqahtani, Promy Virk, Dalia Fouad

Summary: This study assessed the ameliorative potential of Spirulina against DEHP-induced toxicity. The findings revealed that Spirulina effectively reversed the adverse effects of DEHP, providing a nutritional intervention to combat environmental exposure to plasticizers.

ENVIRONMENTAL POLLUTANTS AND BIOAVAILABILITY (2023)

Article Biochemistry & Molecular Biology

Phytotoxicity of sewage sludge passivated by modified potassium feldspar and its effect on ryegrass growth

Tianyu Xie, Fengchun Li, Heng Cao, Chenglong Ge, Wenhao Zhao, Ying Zhao, Xuan Zhang

Summary: Effective passivation of heavy metals in sludge is crucial for its land use. GxK900, a modified potassium feldspar with lower crystallinity, higher specific surface area, and cationic exchange capacity, was chosen to passivate heavy metals in the sludge. The optimal passivation conditions were 30% addition and a 10-day passivation period. The passivated sludge extract had no adverse effects on ryegrass germination and promoted radicle growth. The pot experiment showed that adding 10% passivated sludge enhanced ryegrass growth without significantly affecting the contents of Cu, Cr, Zn, and Pb in the roots and above-ground parts. The transfer factors of the four metals were all less than 1. The use of passivated sludge as a growing medium for landscaping plants provides a theoretical basis for sludge land use and a resource outlet for potassium feldspar minerals.

ENVIRONMENTAL POLLUTANTS AND BIOAVAILABILITY (2023)

Article Biochemistry & Molecular Biology

Assessment of nano-functionalized cellulosic paper for selective estimation of Cr (VI) using diffuse reflectance spectroscopy

Shashwati Wankar, Utkarsh Alset, Rutuja Gumathannavar, K. Nandhini, Neelesh Kumbhojkar, Atul Kulkarni

Summary: In this study, a paper-based sensing system embedded with a novel nano-chromogenic complex was fabricated to detect hexavalent chromium in groundwater. The system utilizes gold nanoparticles modified with 1,5-diphenylcarbazide dye, which turns the paper strip pink within 2 seconds upon interaction with Cr(VI). The optical fiber device developed for detection achieved a limit of detection of 0.02 ppm within a linear range of 0.01-0.4 ppm. RGB color analysis and data-driven predictive modeling demonstrated high accuracy scores for detection.

ENVIRONMENTAL POLLUTANTS AND BIOAVAILABILITY (2023)

Article Biochemistry & Molecular Biology

UiO-66 (Zr-MOF): Synthesis, Characterization, and Application for the Removal of Malathion and 2, 4-D from Aqueous Solution

Bane Kebede Gurmessa, Abi M. Taddesse, Endale Teju

Summary: UiO-66 (Zr-MOF) metal-organic framework was synthesized and characterized. Its efficacy in removing Malathion, 2,4-Dichlorophenoxyacetic acid (2,4-D) and a mixture of the two from water was studied. Various experimental parameters were investigated, and adsorption isotherm and kinetics studies were conducted. The results suggest that UiO-66 (Zr-MOF) shows promise as an effective adsorbent for pesticide removal from aqueous samples.

ENVIRONMENTAL POLLUTANTS AND BIOAVAILABILITY (2023)

Article Biochemistry & Molecular Biology

Determination of aflatoxin M1 (AFM1) in dairy sheep, goats and camel milk in Hail Region, Kingdom of Saudi Arabia and evaluation of different methods reducing its concentrations in milk

Huda Alrashedi, Sawsan Omer, Adibah Almutairi, Gadah Al-Basher, Osama Mohammed

Summary: This study aimed to determine the concentration of AFM1 in dairy sheep, goats, and camel milk in Hail, Saudi Arabia, and evaluate methods for reducing AFM1. The results showed that milk samples from Ghazala had higher levels of AFM1 compared to samples from Al-Shweimis. Microwave heating and boiling were effective in reducing AFM1 in milk samples.

ENVIRONMENTAL POLLUTANTS AND BIOAVAILABILITY (2023)

Article Biochemistry & Molecular Biology

Reclaiming phosphate from aqueous solution using biochar derived from anaerobically digested waste activated sludge and its potential as phosphate fertilizer

Cheng Huang, Lingyi Fan, Kai Zeng, Jinwen Xie, Jianzhong Xiong, Zhimin Liao

Summary: A novel strategy for reclamation and reuse of phosphate from aqueous solution was developed using Mg-enriched biochar prepared from anaerobically digested sludge. The adsorption of phosphate on ADBC-600 could be well described by the pseudo-second-order model and Langmuir model, indicating that the adsorption was mainly dominated by chemisorption process. The spent biochar was also re-utilized as an efficient phosphate fertilizer for improving crop seed germination and growth.

ENVIRONMENTAL POLLUTANTS AND BIOAVAILABILITY (2023)

Review Chemistry, Applied

Curcumin: a bioactive compound with molecular targets for human malignancies

Muhammad Shahbaz, Muhammad Imran, Muzzamal Hussain, Suliman A. Alsagaby, Ushna Momal, Hammad Naeem, Mohamed A. Abdelgawad, Ahmed H. El-Ghorab, Waleed Al Abdulmonem, Ahmed Bilal Waqar, Mohammed M. Ghoneim, Arafa Musa, Entessar Al Jbawi

Summary: Curcumin has anticancer activity by inducing apoptosis and inhibiting proliferation and invasion of tumors through suppressing various cellular signaling pathways. It also possesses anti-tumor activity on different human cancers.

FOOD AND AGRICULTURAL IMMUNOLOGY (2023)