Radiology, Nuclear Medicine & Medical Imaging

Article Radiology, Nuclear Medicine & Medical Imaging

Pitfalls and Common Findings in 68Ga-FAPI PET: A Pictorial Analysis

Lukas Kessler, Justin Ferdinandus, Nader Hirmas, Fadi Zarrad, Michael Nader, David Kersting, Manuel Weber, Sandra Kazek, Miriam Sraieb, Rainer Hamacher, Katharina Lueckerath, Lale Umutlu, Wolfgang P. Fendler, Christoph Rischpler

Summary: This study summarizes common findings and potential pitfalls in Ga-68-FAPI PET/CT. Common findings include uptake in degenerative lesions and head-and-neck. Pitfalls include non-tumor-specific uptake in degenerative lesions, muscle, scarring, mammary glands, or uterus.

JOURNAL OF NUCLEAR MEDICINE (2022)

Review Neurosciences

Consortium neuroscience of attention deficit/hyperactivity disorder and autism spectrum disorder: The ENIGMA adventure

Martine Hoogman, Daan van Rooij, Marieke Klein, Premika Boedhoe, Iva Ilioska, Ting Li, Yash Patel, Merel C. Postema, Yanli Zhang-James, Evdokia Anagnostou, Celso Arango, Guillaume Auzias, Tobias Banaschewski, Claiton H. D. Bau, Marlene Behrmann, Mark A. Bellgrove, Daniel Brandeis, Silvia Brem, Geraldo F. Busatto, Sara Calderoni, Rosa Calvo, Francisco X. Castellanos, David Coghill, Annette Conzelmann, Eileen Daly, Christine Deruelle, Ilan Dinstein, Sarah Durston, Christine Ecker, Stefan Ehrlich, Jeffery N. Epstein, Damien A. Fair, Jacqueline Fitzgerald, Christine M. Freitag, Thomas Frodl, Louise Gallagher, Eugenio H. Grevet, Jan Haavik, Pieter J. Hoekstra, Joost Janssen, Georgii Karkashadze, Joseph A. King, Kerstin Konrad, Jonna Kuntsi, Luisa Lazaro, Jason P. Lerch, Klaus-Peter Lesch, Mario R. Louza, Beatriz Luna, Paulo Mattos, Jane McGrath, Filippo Muratori, Clodagh Murphy, Joel T. Nigg, Eileen Oberwelland-Weiss, Ruth L. O'Gorman Tuura, Kirsten O'Hearn, Jaap Oosterlaan, Mara Parellada, Paul Pauli, Kerstin J. Plessen, J. Antoni Ramos-Quiroga, Andreas Reif, Liesbeth Reneman, Alessandra Retico, Pedro G. P. Rosa, Katya Rubia, Philip Shaw, Tim J. Silk, Leanne Tamm, Oscar Vilarroya, Susanne Walitza, Neda Jahanshad, Stephen Faraone, Clyde Francks, Odile A. van den Heuvel, Tomas Paus, Paul M. Thompson, Jan K. Buitelaar, Barbara Franke

Summary: Neuroimaging has been extensively used to study brain structure and function in individuals with ADHD and ASD. However, there have been limitations in the current literature, such as small sample sizes and heterogeneous methods. To address these limitations, the ENIGMA-ADHD and ENIGMA-ASD working groups were established to collaborate on large-scale neuroimaging projects. The findings so far have shown overlap and unique differences in cortical structures between ASD and ADHD. Ongoing work is exploring other research questions.

HUMAN BRAIN MAPPING (2022)

Editorial Material Radiology, Nuclear Medicine & Medical Imaging

ChatGPT Is Shaping the Future of Medical Writing But Still Requires Human Judgment

Felipe C. Kitamura

RADIOLOGY (2023)

Editorial Material Radiology, Nuclear Medicine & Medical Imaging

Adverse Event Classification: Clarification and Validation of the Society of Interventional Radiology Specialty-Specific System

Mark O. Baerlocher, Boris Nikolic, Daniel Y. Sze

JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY (2023)

Review Neurosciences

Brain functional and effective connectivity based on electroencephalography recordings: A review

Jun Cao, Yifan Zhao, Xiaocai Shan, Hua-liang Wei, Yuzhu Guo, Liangyu Chen, John Ahmet Erkoyuncu, Ptolemaios Georgios Sarrigiannis

Summary: This article reviews recent studies on EEG-based functional and effective connectivity, focusing on estimation, visualization, and machine learning classifier applications. Methods are explored from various dimensions, such as linear or nonlinear, parametric or nonparametric, and time-based, frequency-based or time-frequency-based.

HUMAN BRAIN MAPPING (2022)

Article Neurosciences

Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3-90 years

Danai Dima, Amirhossein Modabbernia, Efstathios Papachristou, Gaelle E. Doucet, Ingrid Agartz, Moji Aghajani, Theophilus N. Akudjedu, Anton Albajes-Eizagirre, Dag Alnaes, Kathryn Alpert, Micael Andersson, Nancy C. Andreasen, Ole A. Andreassen, Philip Asherson, Tobias Banaschewski, Nuria Bargallo, Sarah Baumeister, Ramona Baur-Streubel, Alessandro Bertolino, Aurora Bonvino, Dorret Boomsma, Stefan Borgwardt, Josiane Bourque, Daniel Brandeis, Alan Breier, Henry Brodaty, Rachel M. Brouwer, Jan K. Buitelaar, Geraldo F. Busatto, Randy L. Buckner, Vincent Calhoun, Erick J. Canales-Rodriguez, Dara M. Cannon, Xavier Caseras, Francisco X. Castellanos, Simon Cervenka, Tiffany M. Chaim-Avancini, Christopher R. K. Ching, Victoria Chubar, Vincent P. Clark, Patricia Conrod, Annette Conzelmann, Benedicto Crespo-Facorro, Fabrice Crivello, Eveline A. Crone, Anders M. Dale, Cristopher Davey, Eco J. C. de Geus, Lieuwe de Haan, Greig de Zubicaray, Anouk den Braber, Erin W. Dickie, Annabella Di Giorgio, Nhat Trung Doan, Erlend S. Dorum, Stefan Ehrlich, Susanne Erk, Thomas Espeseth, Helena Fatouros-Bergman, Simon E. Fisher, Jean-Paul Fouche, Barbara Franke, Thomas Frodl, Paola Fuentes-Claramonte, David C. Glahn, Ian H. Gotlib, Hans-Joergen Grabe, Oliver Grimm, Nynke A. Groenewold, Dominik Grotegerd, Oliver Gruber, Patricia Gruner, Rachel E. Gur, Ruben C. Gur, Ben J. Harrison, Catharine A. Hartman, Sean N. Hatton, Andreas Heinz, Dirk J. Heslenfeld, Derrek P. Hibar, Ian B. Hickie, Beng-Choon Ho, Pieter J. Hoekstra, Sarah Hohmann, Avram J. Holmes, Martine Hoogman, Norbert Hosten, Fleur M. Howells, Hilleke E. Hulshoff Pol, Chaim Huyser, Neda Jahanshad, Anthony James, Terry L. Jernigan, Jiyang Jiang, Erik G. Jonsson, John A. Joska, Rene Kahn, Andrew Kalnin, Ryota Kanai, Marieke Klein, Tatyana P. Klyushnik, Laura Koenders, Sanne Koops, Bernd Kraemer, Jonna Kuntsi, Jim Lagopoulos, Luisa Lazaro, Irina Lebedeva, Won Hee Lee, Klaus-Peter Lesch, Christine Lochner, Marise W. J. Machielsen, Sophie Maingault, Nicholas G. Martin, Ignacio Martinez-Zalacain, David Mataix-Cols, Bernard Mazoyer, Colm McDonald, Brenna C. McDonald, Andrew M. McIntosh, Katie L. McMahon, Genevieve McPhilemy, Jose M. Menchon, Sarah E. Medland, Andreas Meyer-Lindenberg, Jilly Naaijen, Pablo Najt, Tomohiro Nakao, Jan E. Nordvik, Lars Nyberg, Jaap Oosterlaan, Victor Ortiz-Garcia De la Foz, Yannis Paloyelis, Paul Pauli, Giulio Pergola, Edith Pomarol-Clotet, Maria J. Portella, Steven G. Potkin, Joaquim Radua, Andreas Reif, Daniel A. Rinker, Joshua L. Roffman, Pedro G. P. Rosa, Matthew D. Sacchet, Perminder S. Sachdev, Raymond Salvador, Pascual Sanchez-Juan, Salvador Sarro, Theodore D. Satterthwaite, Andrew J. Saykin, Mauricio H. Serpa, Lianne Schmaal, Knut Schnell, Gunter Schumann, Kang Sim, Jordan W. Smoller, Iris Sommer, Carles Soriano-Mas, Dan J. Stein, Lachlan T. Strike, Suzanne C. Swagerman, Christian K. Tamnes, Henk S. Temmingh, Sophia Thomopoulos, Alexander S. Tomyshev, Diana Tordesillas-Gutierrez, Julian N. Trollor, Jessica A. Turner, Anne Uhlmann, Odile A. van den Heuvel, Dennis van den Meer, Nic J. A. van der Wee, Neeltje E. M. van Haren, Dennis Van't Ent, Theo G. M. van Erp, Ilya M. Veer, Dick J. Veltman, Aristotle Voineskos, Henry Voelzke, Henrik Walter, Esther Walton, Lei Wang, Yang Wang, Thomas H. Wassink, Bernd Weber, Wei Wen, John D. West, Lars T. Westlye, Heather Whalley, Lara M. Wierenga, Steven C. R. Williams, Katharina Wittfeld, Daniel H. Wolf, Amanda Worker, Margaret J. Wright, Kun Yang, Yulyia Yoncheva, Marcus Zanetti, Georg C. Ziegler, Paul M. Thompson, Sophia Frangou

Summary: Age has a significant impact on brain volume, with different regions showing varying trajectories. Basal ganglia volume decreases with age, while lateral ventricles continue to enlarge. These findings provide important insights into the functional significance of age-related morphometric patterns in the brain.

HUMAN BRAIN MAPPING (2022)

Article Biochemical Research Methods

Label-free plasmonic immunosensor for cortisol detection in a D-shaped optical fiber

M. A. R. I. A. S. SOARES, L. U. I. S. C. B. SILVA, M. I. G. U. E. L. VIDAL, M. E. D. E. R. I. C. LOYEZ, M. A. R. G. A. R. I. D. A. FACAO, C. H. R. I. S. T. O. P. H. E. CAUCHETEUR, M. A. R. C. E. L. O. E. V. SEGATTO, F. L. O. R. I. N. D. A. M. COSTA, C. A. T. I. A. LEITAO, S. O. N. I. A. O. PEREIRA, N. U. N. O. F. SANTOS, C. A. R. L. O. S. A. F. MARQUES

Summary: Measuring cortisol levels as a stress biomarker is crucial in medical conditions associated with a high risk of metabolic syndromes. Fiber optic biosensors have gained increasing interest due to their ability to detect cortisol with high sensitivity.

BIOMEDICAL OPTICS EXPRESS (2022)

Article Radiology, Nuclear Medicine & Medical Imaging

Albumin Binder-Conjugated Fibroblast Activation Protein Inhibitor Radiopharmaceuticals for Cancer Therapy

Mengxin Xu, Pu Zhang, Jie Ding, Junyi Chen, Li Huo, Zhibo Liu

Summary: This study developed and evaluated two albumin-binder conjugated FAPI radiopharmaceuticals (TEFAPI-06 and TEFAPI-07) to address the issue of fast clearance and insufficient tumor retention. The results showed significantly improved tumor accumulation and retention compared to the original FAPI tracer, and these radiopharmaceuticals demonstrated remarkable growth inhibition of PDX tumors with negligible side effects.

JOURNAL OF NUCLEAR MEDICINE (2022)

Article Radiology, Nuclear Medicine & Medical Imaging

First In-Human Results of Computed Tomography Angiography for Coronary Stent Assessment With a Spectral Photon Counting Computed Tomography

Sara Boccalini, Salim A. Si-Mohamed, Hugo Lacombe, Adja Diaw, Mohammad Varasteh, Pierre-Antoine Rodesch, Marjorie Villien, Monica Sigovan, Riham Dessouky, Philippe Coulon, Yoad Yagil, Elias Lahoud, Klaus Erhard, Gilles Rioufol, Gerard Finet, Eric Bonnefoy-Cudraz, Cyrille Bergerot, Loic Boussel, Philippe C. Douek

Summary: This study compared the image quality of in vivo coronary stents between an energy integrating detectors dual-layer computed tomography (EID-DLCT) and a clinical prototype of spectral photon counting computed tomography (SPCCT). The results showed that SPCCT demonstrated improved objective and subjective image quality compared to EID-DLCT, even with a reduced radiation dose.

INVESTIGATIVE RADIOLOGY (2022)

Review Acoustics

New International Guidelines and Consensus on the Use of Lung Ultrasound

Libertario Demi, Frank Wolfram, Catherine Klersy, Annalisa De Silvestri, Virginia Valeria Ferretti, Marie Muller, Douglas Miller, Francesco Feletti, Marcin Welnicki, Natalia Buda, Agnieszka Skoczylas, Andrzej Pomiecko, Domagoj Damjanovic, Robert Olszewski, Andrew W. Kirkpatrick, Raoul Breitkreutz, Gebhart Mathis, Gino Soldati, Andrea Smargiassi, Riccardo Inchingolo, Tiziano Perrone

Summary: A multidisciplinary panel of international LUS experts reviewed and updated the international consensus for point-of-care LUS, resulting in 20 statements with guidelines and future development proposals in the areas of technical, clinical, educational, and safety aspects.

JOURNAL OF ULTRASOUND IN MEDICINE (2023)

Article Radiology, Nuclear Medicine & Medical Imaging

The potential utility of [68 Ga]Ga-DOTA-FAPI-04 as a novel broad-spectrum oncological and non-oncological imaging agent-comparison with [18F]FDG

Lianjun Lan, Hanxiang Liu, Yingwei Wang, Jia Deng, Dengsai Peng, Yue Feng, Li Wang, Yue Chen, Lin Qiu

Summary: The study aimed to compare the detection performance of [(68) Ga]Ga-DOTA-FAPI-04 and [F-18]FDG PET/CT in patients with various oncological and non-oncological lesions. [(68) Ga]Ga-DOTA-FAPI-04 PET/CT showed significantly higher uptake and detection rate for primary, nodal, and distant metastatic lesions of solid tumors compared to [F-18]FDG PET/CT. Except for myeloma and lymphoma, [(68) Ga]Ga-DOTA-FAPI-04 PET/CT demonstrated superior detection efficacy for various primary and metastatic lesions than [F-18]FDG PET/CT.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2022)

Article Radiology, Nuclear Medicine & Medical Imaging

Radiomic machine learning for predicting prognostic biomarkers and molecular subtypes of breast cancer using tumor heterogeneity and angiogenesis properties on MRI

Ji Young Lee, Kwang-Sig Lee, Bo Kyoung Seo, Kyu Ran Cho, Ok Hee Woo, Sung Eun Song, Eun-Kyung Kim, Hye Yoon Lee, Jung Sun Kim, Jaehyung Cha

Summary: This study investigated machine learning approaches for radiomics-based prediction of prognostic biomarkers and molecular subtypes of breast cancer using MRI, with texture and perfusion analyses. Texture and perfusion parameters were associated with hormone receptors, Ki67, grade, and molecular subtypes. The random forest model integrating texture and perfusion parameters showed the highest performance, with important parameters for prediction being texture irregularity (entropy) and relative extracellular extravascular space (V-e).

EUROPEAN RADIOLOGY (2022)

Article Radiology, Nuclear Medicine & Medical Imaging

Ultra-high dose rate electron beams and the FLASH effect: From preclinical evidence to a new radiotherapy paradigm

Emil Schuler, Munjal Acharya, Pierre Montay-Gruel, Billy W. Jr Jr Loo, Marie-Catherine Vozenin, Peter G. Maxim

Summary: This article reviews the studies published after Fauvadon et al.'s seminal paper from 2014, demonstrating the robust effects of FLASH radiation therapy (RT) on normal tissue sparing in preclinical models. It points out the differences in the magnitude of the FLASH effect between experiments in different labs and proposes a new standard for beam parameter reporting and a systematic path to the clinical translation of FLASH RT.

MEDICAL PHYSICS (2022)

Article Radiology, Nuclear Medicine & Medical Imaging

Contrast-Enhanced Abdominal CT with Clinical Photon-Counting Detector CT: Assessment of Image Quality and Comparison with Energy-Integrating Detector CT

Kai Higashigaito, Andre Euler, Matthias Eberhard, Thomas G. Flohr, Bernhard Schmidt, Hatem Alkadhi

Summary: Intra-individual comparison of abdominal PCD-CT showed significantly higher CNR in VMI at 50 keV with similar subjective image quality compared to EID-CT at the same radiation dose.

ACADEMIC RADIOLOGY (2022)

Article Neurosciences

Triaxial detection of the neuromagnetic field using optically-pumped magnetometry: feasibility and application in children

Elena Boto, Vishal Shah, Ryan M. Hill, Natalie Rhodes, James Osborne, Cody Doyle, Niall Holmes, Molly Rea, James Leggett, Richard Bowtell, Matthew J. Brookes

Summary: Optically-pumped magnetometers (OPMs) are a viable alternative to superconducting sensors for magnetoencephalography (MEG), with advantages such as flexibility, uniform coverage, better data quality, and lower cost. This study introduces a novel triaxial OPM sensor that can accurately and sensitively measure magnetic fields, showing comparable performance to conventional OPMs. A child-friendly 3D-printed OPM-helmet is also proposed, demonstrating the feasibility of triaxial measurement in pediatric populations.

NEUROIMAGE (2022)

Review Neurosciences

Mapping brain asymmetry in health and disease through the ENIGMA consortium

Xiang-Zhen Kong, Merel C. Postema, Tulio Guadalupe, Carolien de Kovel, Premika S. W. Boedhoe, Martine Hoogman, Samuel R. Mathias, Daan van Rooij, Dick Schijven, David C. Glahn, Sarah E. Medland, Neda Jahanshad, Sophia Thomopoulos, Jessica A. Turner, Jan Buitelaar, Theo G. M. van Erp, Barbara Franke, Simon E. Fisher, Odile A. van den Heuvel, Lianne Schmaal, Paul M. Thompson, Clyde Francks

Summary: Left-right asymmetry of the human brain is associated with psychiatric disorders, but previous research findings have been inconsistent. The ENIGMA-Laterality Working Group conducted large-scale studies and mapped the average asymmetry in healthy brains. They also found associations between brain asymmetry and age, sex, handedness, and brain volume. Moreover, they identified subtle changes in cortical thickness asymmetry in autism spectrum disorder and altered subcortical asymmetry in pediatric obsessive-compulsive disorder.

HUMAN BRAIN MAPPING (2022)

Article Neurosciences

Greater male than female variability in regional brain structure across the lifespan

Lara M. Wierenga, Gaelle E. Doucet, Danai Dima, Ingrid Agartz, Moji Aghajani, Theophilus N. Akudjedu, Anton Albajes-Eizagirre, Dag Alnaes, Kathryn Alpert, Ole A. Andreassen, Alan Anticevic, Philip Asherson, Tobias Banaschewski, Nuria Bargallo, Sarah Baumeister, Ramona Baur-Streubel, Alessandro Bertolino, Aurora Bonvino, Dorret Boomsma, Stefan Borgwardt, Josiane Bourque, Anouk den Braber, Daniel Brandeis, Alan Breier, Henry Brodaty, Rachel M. Brouwer, Jan K. Buitelaar, Geraldo F. Busatto, Vince D. Calhoun, Erick J. Canales-Rodriguez, Dara M. Cannon, Xavier Caseras, Francisco X. Castellanos, Tiffany M. Chaim-Avancini, Christopher R. K. Ching, Vincent P. Clark, Patricia J. Conrod, Annette Conzelmann, Fabrice Crivello, Christopher G. Davey, Erin W. Dickie, Stefan Ehrlich, Dennis Van't Ent, Simon E. Fisher, Jean-Paul Fouche, Barbara Franke, Paola Fuentes-Claramonte, Eco J. C. de Geus, Annabella Di Giorgio, David C. Glahn, Ian H. Gotlib, Hans J. Grabe, Oliver Gruber, Patricia Gruner, Raquel E. Gur, Ruben C. Gur, Tiril P. Gurholt, Lieuwe de Haan, Beathe Haatveit, Ben J. Harrison, Catharina A. Hartman, Sean N. Hatton, Dirk J. Heslenfeld, Odile A. van den Heuvel, Ian B. Hickie, Pieter J. Hoekstra, Sarah Hohmann, Avram J. Holmes, Martine Hoogman, Norbert Hosten, Fleur M. Howells, Hilleke E. Hulshoff Pol, Chaim Huyser, Neda Jahanshad, Anthony C. James, Jiyang Jiang, Erik G. Jonsson, John A. Joska, Andrew J. Kalnin, Marieke Klein, Laura Koenders, Knut K. Kolskar, Bernd Kramer, Jonna Kuntsi, Jim Lagopoulos, Luisa Lazaro, Irina S. Lebedeva, Phil H. Lee, Christine Lochner, Marise W. J. Machielsen, Sophie Maingault, Nicholas G. Martin, Ignacio Martinez-Zalacain, David Mataix-Cols, Bernard Mazoyer, Brenna C. McDonald, Colm McDonald, Andrew M. McIntosh, Katie L. McMahon, Genevieve McPhilemy, Dennis van der Meer, Jose M. Menchon, Jilly Naaijen, Lars Nyberg, Jaap Oosterlaan, Yannis Paloyelis, Paul Pauli, Giulio Pergola, Edith Pomarol-Clotet, Maria J. Portella, Joaquim Radua, Andreas Reif, Genevieve Richard, Joshua L. Roffman, Pedro G. P. Rosa, Matthew D. Sacchet, Perminder S. Sachdev, Raymond Salvador, Salvador Sarro, Theodore D. Satterthwaite, Andrew J. Saykin, Mauricio H. Serpa, Kang Sim, Andrew Simmons, Jordan W. Smoller, Iris E. Sommer, Carles Soriano-Mas, Dan J. Stein, Lachlan T. Strike, Philip R. Szeszko, Henk S. Temmingh, Sophia Thomopoulos, Alexander S. Tomyshev, Julian N. Trollor, Anne Uhlmann, Ilya M. Veer, Dick J. Veltman, Aristotle Voineskos, Henry Volzke, Henrik Walter, Lei Wang, Yang Wang, Bernd Weber, Wei Wen, John D. West, Lars T. Westlye, Heather C. Whalley, Steven C. R. Williams, Katharina Wittfeld, Daniel H. Wolf, Margaret J. Wright, Yuliya N. Yoncheva, Marcus Zanetti, Georg C. Ziegler, Greig de Zubicaray, Paul M. Thompson, Eveline A. Crone, Sophia Frangou, Christian K. Tamnes

Summary: Males exhibit greater variability than females in many traits, which may have implications for understanding sex differences in health and disease. A mega-analysis of brain structure variability based on MRI data of 16,683 healthy individuals spanning nine decades of life reveals significant patterns of greater male than female between-subject variance in subcortical volumes, cortical surface area, and cortical thickness. These sex differences are present in childhood and may be influenced by early life genetic or gene-environment interaction mechanisms. The findings underscore the importance of individual differences within each sex, which may contribute to sex-specific vulnerability to disorders.

HUMAN BRAIN MAPPING (2022)

Review Cardiac & Cardiovascular Systems

Tricuspid regurgitation: recent advances in understanding pathophysiology, severity grading and outcome

Rebecca T. Hahn, Luigi P. Badano, Philipp E. Bartko, Denisa Muraru, Francesco Maisano, Jose L. Zamorano, Erwan Donal

Summary: Heightened interest in tricuspid regurgitation (TR) is due to the association of mortality with severity of TR and low surgical treatment use. With the development of transcatheter solutions, there is a growing need to understand and diagnose the disease for appropriate management.

EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING (2022)

Article Radiology, Nuclear Medicine & Medical Imaging

First-in-Humans Evaluation of a PD-L1-Binding Peptide PET Radiotracer in Non-Small Cell Lung Cancer Patients

Xin Zhou, Jinquan Jiang, Xue Yang, Teli Liu, Jin Ding, Sridhar Nimmagadda, Martin G. Pomper, Hua Zhu, Jun Zhao, Zhi Yang, Nan Li

Summary: In this study, the peptide-based PET imaging agent 68Ga-NOTA-WL12 was used to investigate its in vivo biodistribution and metabolism in patients with advanced non-small cell lung cancer. The results demonstrated the potential clinical benefits of using 68Ga-NOTA-WL12 for non-invasive detection of tumor PD-L1 expression levels.

JOURNAL OF NUCLEAR MEDICINE (2022)

Article Radiology, Nuclear Medicine & Medical Imaging

Ultra-High-Resolution Coronary CT Angiography With Photon-Counting Detector CT Feasibility and Image Characterization

Victor Mergen, Thomas Sartoretti, Matthias Baer-Beck, Bernhard Schmidt, Martin Petersilka, Joachim Ernst Wildberger, Andre Euler, Matthias Eberhard, Hatem Alkadhi

Summary: This study evaluated the feasibility and quality of ultra-high-resolution CCTA with PCD-CT in patients with high coronary calcium load, showing that ultra-high-resolution CCTA was feasible in all patients and provided excellent image quality with high sharpness and reduced blooming.

INVESTIGATIVE RADIOLOGY (2022)